加味异功散方联合艾迪注射液治疗中晚期胃癌临床的研究.docVIP

加味异功散方联合艾迪注射液治疗中晚期胃癌临床的研究 　　摘要：目的 观察加味异功散方联合艾迪注射液对中晚期胃癌的临床疗效。方法 将64例中晚期胃癌患者随机分为治疗组和对照组各32例。2组均予艾迪注射液静脉滴注，连续2周。治疗组在此基础上加服加味异功散方，每日1剂，午饭后口服，连续4周；对照组不加服其他药物。观察2组患者治疗前后肿瘤标志物（CEA、CA199）、中医证候积分及体力状况评分。结果 治疗组治疗后中医证候积分明显优于对照组（P0.05）。结论 加味异功散方联合艾迪注射液对中晚期胃癌的肿瘤标志物改善不明显，但对患者中医证候和体力状况的改善非常明显。 　　关键词：加味异功散方；艾迪注射液；中晚期胃癌 　　DOI：10.3969/j.issn.1005-5304.2016.06.010 　　中图分类号：R273.52 文献标识码：A 文章编号：1005-5304（2016）06-0035-04 　　Abstract： Objective To observe the clinical efficacy of Modified Yigongsan Formula combined with Aidi-injection on advanced gastric cancer. Methods Totally 64 cases of patients with advanced gastric cancer were randomly divided into treatment group and control group with 32 cases in each group. Both groups were treated with Aidi-injection for intravenous drip， continuous infusion for 2 weeks. The treatment group was treated with Modified Yigongsan Formula， daily 1 agent， oral administration after lunch， for 4 weeks continuously； the control group did not take other medicine. The tumor markers （CEA， CA199）， TCM syndrome score and physical condition score of the patients before and after treatment were observed. Results After treatment， the TCM syndrome score in the treatment group was significantly improved than that in the control group； the total effective rate was 84.38% （27/32） in the treatment group， and 43.75% （14/32） in the control group； the treatment group was significantly higher than that in the control group （P0.05）. Conclusion Modified Yigongsan Formula combined with Aidi-injection on advanced gastric cancer tumor marker improvement was not obvious， but the improvement of TCM syndrome and physical condition of patients is very obvious. 　　Key words： Modified Yigongsan Formula； Aidi-injection； advanced gastric cancer 　　胃癌发生于胃黏膜的上皮细胞，早期患者往往没有明显自觉症状，经常到中晚期才被发现，已经错过手术的最佳时机，而以药物治疗为主要治疗手段[1]。笔者选择64例中晚期胃癌患者，分别采用加味异功散方联合艾迪注射液及单用艾迪注射液2种方案治疗，观察加味异功散方联合抗癌中成药对中晚期胃癌患者在扶正抑瘤、改善临床症状等方面的疗效，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　64例均来源于2010年1月-2014年6月本院肿瘤科住院的中晚期胃癌患者。按入院时间排