超临界溶液快速膨胀法制备超细药物粒子-化学工程与技术专业论文.docxVIP

II II Abstract Not only chemical structures, but also the particle size and morphology decide the effect of the pharmaceuticals. Higher bioavailability can be obtained with smaller particle size and larger particle specific surface area, so the research of producing fine particles is very profound. Rapid Expansion of Supercritical Solutions (RESS) is a rapidly developing supercritical technology to micronize drug particles, due to a series of attractive advantages offered by the RESS process, such as without solvent residual product, nonhazardous, non-pollution, mild operating condition and low energy consumption, the RESS process has attached more and more importance to research on micronization of drug particles. The solubility of risocaine and phenacetin in supercritical carbon dioxide were measured by the static method at different experiment conditions, the empirical model and EOS model were applied to correlate those solubility data and the results comparison was studied. Fine particles were obtained by the RESS and the effect of important operating parameters were evaluated by the analysis of SEM figures. The solubility of risocaine has been measured by the static method under different operating conditions in this paper. It has been examined that the solubility of risocaine increases with the increase of pressure and decreases with the increase of temperature, which was reached to 10-4 mol/mol. The results of pressure (9.0-30.0 MPa) and temperature (308.0-328.0 K) on solubility show that the solubility increases mainly with increasing density. Results show that a reverse region where the solubility of phenacetin decreases with the increase in temperature appears at a pressure of 9.0 MPa. The mole fraction solubility of phenacetin was reached to 10–5. The empirical model and EOS model were applied to correlate the experimental data of risocaine. Agreement between experimental data and model predictions are better with Chrastil model and Adachi-Lu modified Chr