多重耐药鲍曼不动杆菌感染重症肺炎患者预后相关因素分析-内科学专业论文.docxVIP

目 录 中文摘要························································································································1 英文摘要························································································································4 研究论文 多重耐药鲍曼不动杆菌感染重症肺炎患者预后相关因素分析 前言························································································································8 材料与方法························································································································10 结果························································································································12 附表························································································································14 讨论························································································································17 结论························································································································22 参考文献························································································································23 综述 鲍曼不动杆菌的耐药机制及治疗策略研究进展··········································26 致谢························································································································37 个人简历························································································································38 多重耐药鲍曼不动杆菌感染重症肺炎患者预后相关因素分析 摘 要 目的：肺炎（pneumonia）是指终末气道、肺泡和肺间质的炎症，是 一种临床常见病和多发病。重症肺炎更是医院内呼吸内科及各类重症监护 病房常见的危重症，常全身多脏器功能受累，往往病情进展迅速，预后不 良，尽管随着现代医学技术的不断提高，重症肺炎的病死率仍居高不下。 鲍曼不动杆菌（acinetobacter baumannii）是我国医院内感染常见的重要的 病原菌之一，其主要定植部位为人类呼吸道，近年来现有抗生素对鲍曼不 动杆菌对的敏感性越来越差，该菌耐药性呈上升趋势，临床上治疗困难重 重，感染患者的病死率较前升高。本研究旨在分析多重耐药鲍曼不动杆菌 感染重症肺炎患者的临床特点，探讨与其预后的相关危险因素，对疾病的 病情和预后发展能够给予有效的评估和预测，尽可能为鲍曼不动杆菌感染 重症肺炎患者的治疗提供相关的依据。 方法： 1 选取 2015-3 月份到 2015-10 月份期间河北医科大学附属第二医院 呼吸二科 ICU 中多重耐药鲍曼不动杆菌重症肺炎诊断明确的患者总共 60 例，入选病例符合 2016 年修订的中国成人社区获得性肺炎诊断