创伤后创面铜绿假单胞菌生物膜感染的治疗策略-外科专业论文.docxVIP

英汉缩略语名词对照 英文缩写 英文全称 中文全称 PA Pseudomonas aeruginosa 铜绿假单胞菌 BBF Bacterial Biofilm 细菌生物膜 EPS exopolysaccharide 胞外多糖 AHL N—acyl homoserine lactones N 一酰基高丝氨酸内 酯 MIC Minimal Inhibitory Concentration 最小抑菌浓度 QS Quorum-sensing system 细菌群体感应系统 QSI Quorum-sensing inhibitor 细菌群体感应抑制剂 ALA 5-aminolevulinic acid 氨基酮戊酸 TBO Toluidine blue O 甲苯胺蓝 O GTF galctosyl- hydroxylysyl glucosyl transferase 葡萄糖转移酶 CLSM Confocal laser microscopy 激光共聚焦扫描显微 镜 PACT Photodynamic Antimicrobial chemotherapy MIC Minimal Inhibitory Concentration 光动力抗微生物 化学 治疗 最小抑菌浓度 AMP Antimicrobioal peptide 抗菌肽（抗微生物肽） 1 创伤后创面铜绿假单胞菌生物膜感染的治疗策略 摘 要 创伤广泛存在于人们的日常生活中，其发生率很高。创伤不但造 成机体的伤害，而且创伤后细菌的感染导致创面难于愈合，使得机体 防御力不能恢复，细菌进入血液造成菌血症及败血症等，严重威胁着 人类生命安全。创伤后早期不清创以及清创不彻底都是导致创伤后相 关创面的感染率日益升高的原因。近年来对各种抗菌药物的滥用导致 各种细菌微生物耐药性增强，某些耐药菌的治疗就显得格外棘手。国 内外学者研究发现细菌的主要耐药机制在于细菌生物膜的形成，在创 伤后创面细菌感染生物膜形成后对药物有明显的抵抗作用，创面愈合 时间延长，令临床医生很棘手，同时增加病人的痛苦。因此防治及消 除细菌生物膜成为近年来抗菌的“新靶点”。本文就以创伤后创面铜 绿假单胞菌生物膜感染治疗策略为例，从创伤、创伤感染、铜绿假单 胞菌及其生物膜、创伤后创面铜绿假单胞菌生物膜治疗策略等方面进 行综述，为临床创面的抗菌治疗提供新思路，寻求新方法。 关键词：创伤；创伤后感染；绿假单胞菌及其生物膜感染；治疗 策略 2 TREAMENT STRATEGIE OF THE INFECTION OF PSEUDOMONAS AERUGINOSA B IOFILM AFTER TRAUMA ABSTRACT Trauma widely exists in Peoples Daily life, its incidence is very high.It is not only harmful to the body, trauma and post-traumatic bacterial infections for the wound hard to heal, makes the human immunity cant recover, bacteria invading into the blood stream cause bacteremia and sepsis makes a serious threat to peoples life safety. Post-traumatic without timely debridement and debridement imcompletely lead to posttraumatic wound infection rate rising. Misuse of bacterial resistance to antibiotics in recent years, especially in the treatment of certain bacterial is particularly tricky. Scholars at home and abroad in recent years, the study found that the bacteria mainly resistance mechanism lies in the formation of bacterial biofilm, bacterial biofilm formation in posttraumatic wound after have obvious resistance to drugs, poor wound healing, the clinical d