儿童急性白血病化疗期间骨髓抑制合并感染时降钙素原意义-儿科学专业论文.docxVIP

个人简历.............................................................................................................................. 33 儿童急性白血病化疗期间骨髓抑制合并感染时降钙素原意义 摘 要 儿童急性白血病在小儿肿瘤性疾病中常见的疾病。近期随着化疗以及联合骨髓移 植的开展，儿童疾病白血病的预后得到了极大改善，但是化疗期间易合并骨髓抑制， 此时极易发生感染，这是威胁这类儿童长期生存的最大不利因素之一。对于化疗后骨 髓抑制感染早期诊断与治疗成为临床上一大挑战，严重感染不但延误化疗时机同时感 染不易控制可危及生命。降钙素原作为一种细菌感染早期的敏感指标，可以作为急性 白血病患儿骨髓抑制合并感染早期临床诊断方法之一。 目的: 探讨在急性白血病患儿骨髓抑制合并感染时不同降钙素原数值的意义。 方法: 采用回顾性研究方法测定降钙素原测定山西省儿童医院血液科病房 102 例白血 病患儿感染初期血清降钙素原数值，根据感染种类分为细菌感染组（50 例），非细 菌感染组（52 例），根据骨髓抑制程度所导致感染风险分为高危风险感染组(75 例)， 低危风险感染组（27 例），同期将门诊 50 例未发生感染及骨髓抑制的完全缓解期急 性白血病门诊复查病人作为对照。以检测血常规及降钙素原值，采用秩和检验等相关 统计学方法进行相关比较分析。 结果: 细菌感染组降钙素原水平中位数 0.615ng/mL，且随着感染严重程度而增加，非 细菌感染组降钙素原水平明显低于细菌感染时降钙素原水平，但要高于对照组水平。 结论: 降钙素原值水平可作为儿童急性白血病骨髓抑制合并感染早期诊断标准之一，同 时可评估感染严重程度。 关键词：儿童；急性白血病；骨髓抑制；降钙素原 The Meaning Of Procalcitonin When Children With Acute Leukemia Infected During Chemotheropy Mergeing Bone Marrow Suppression Abstract Children acute leukemia is one of the common disease in children tumor diseases. Recently ,with the development of chemotherapy as well as the joint bone marrow transplant, the prognosis of leukemia children disease significantly improved. But easy to merge bone marrow suppression during chemotherapy ,and extremely easy infection occurs at this time, which is the biggest threat to this kind of childrens long-term survival disadvantage factor. On early diagnosis and treatment of bone marrow suppression after chemotherapy infections become a big challenge, clinically severe infection not only delay time of chemotherapy can be a life-threatening infection is not easy to control at the same time. Procalcitonin as a kind of bacterial infection early sensitive indicators, can be used as children with acute leukemia bone marrow suppression merge infection is one of the early clinical diagnosis method. Objective : To explore the complicated infections in children with acute leukemia bone marrow suppression in different procalcitonin the meaning of the original value