二甲双胍对实验性自身免疫性脑脊髓炎的保护作用及作用机制探讨-神经病学专业论文.docx

目 录 中文摘要············································································································································1 英文摘要············································································································································9 英文缩写··········································································································································16 研究论文 二甲双胍对实验性自身免疫性脑脊髓炎的保护作用及作用机 制探讨 引言··········································································································································18 第一部分 二甲双胍通过调节 Th17/Treg 细胞平衡改善实验性自身免疫 性脑脊髓炎病情 前言··········································································································································21 材料与方法···························································································································23 结果··········································································································································34 附图··········································································································································38 讨论··········································································································································44 小结··········································································································································48 参考文献································································································································49 第二部分 AMPK/mTOR 信号通路中涉及代谢的分子在实验性自身免疫 性脑脊髓炎疾病中的动态变化 前言··········································································································································53 材料与方法···························································································································55 结果···························