促血管内皮生长相关因子在高原心脏病患者血液中的表达及其在发病中作用的初步研究-高原医学专业论文.docxVIP

A Preliminary study on the expression of vascular endothelial growth factor in patients with high altitude heart disease and the relationship of them Abstract Background and purpose : Tibet, with its rich natural and tourism resources, is Chinas important strategic region. Heart disease caused by high altitude is always the main threat of the health of people living in highland. Recently, High Altitude Heart Disease (HAHD) has been incorporated into the category of occupational disease, because of its high morbidity and poor prognosis. HAHD has brought great suffering to people in high altitude region physically and mentally, causing huge economic burden to the society and military [1]. Many studies have proven that hypoxic pulmonary hypertension (HPH) plays a key role in HAHD [2]. However, the mechanism of HPH is very complicated and hard to be explained by a single mechanism, which involves cells, body fluids, and even molecular genetics. Meanwhile, vasoconstriction and pulmonary vascular structural remodeling (PVSR) are the important pathophysiological basis of the causing of HPH [4,6]. The previous studies of heart disease in the highlands are mostly based on clinical analysis. We perform this study in the highlands and start it with humoral transmitter. By observing clinical symptoms and signs, taking routine laboratory examination, promoting vascular endothelial growth expression factor levels and so on, we analyze the clinical features of patients. On studying vascular endothelial growth factor expression level in blood detection, we preliminarily discuss the mechanism of these factors in the pathogenesis of HAHD, so as to provide theoretic basis for high altitude clinical prevention and treatment. Subjects and Methods : Object: 107 cases with high altitude heart disease are collected from the outpatients, inpatients or suspected heart disease inpatients in Tibet military region general hospital from March 2012 to April 2012. According to the inclusion and e