乳铁蛋白治疗儿童轮状病毒肠炎疗效剖析.docVIP

乳铁蛋白治疗儿童轮状病毒肠炎疗效剖析 　　[摘要] 目的 探讨乳铁蛋白在治疗轮状病毒肠炎患儿中的疗效。 方法 收集郑州市第一人民医院2013年9月～2014年3月住院部腹泻患儿的粪便标本210份，采用ELISA方法检测RV抗原，将轮状病毒阳性患儿118例随机分为观察组59例和对照组59例，对照组给予补液、补充微生态制剂、调整饮食等，观察组在对照组基础上加用乳铁蛋白口服，比较两组治疗有效率、症状缓解时间、住院时间及不良反应。 结果 观察组患儿总有效率94.9%（56/59），高于对照组的72.9%（43/59），差异有统计学意义（P0.05）；观察组患儿治疗效果、症状缓解时间、住院时间均优于对照组（P0.05）。两组患儿均无严重不良反应发生。 结论 乳铁蛋白治疗轮状病毒肠炎患儿的疗效确切，不良反应较小。 　　[关键词] 轮状病毒；肠炎；儿童；乳铁蛋白 　　[中图分类号] R725.1 [文献标识码] B [文章编号] 1673-9701（2015）35-0074-03 　　[Abstract] Objective To investigate the effect of lactoferrin in treatment of rotavirus enteritis in children. Methods Stool samples were collected from 210 children who were hospitalized in the department of peadiatric， the First peoples Hospital of Zhengzhou from September 2013 to March 2014. Enzyme linked immunosor- bent assay（ELISA） was used to detect rotavirus antigen. The 118 positive samples were randomly divided into observation group and control group. 59 cases in each group. Control group was treated with the fluid infusion， microecologics， dietary adjustment etc， while the observation group received lactoferrin on the basis of the same treatment as control group. The curative rate， time of the symptoms alleviated， length of the hospitalizationa and adverse reactions of the two groups were compared. Results The total effective rate of observation group was 94.9%（56/59）， which was higer than 72.9%（43/59） of control group. The difference had statistical diftference（P0.05）. The curative rate， time of the symptoms alleviated， length of the hospitalization of the observation were superior than the control group， there were no serious adverse reactions of the two groups. Conclusion Lactoferrin has exact effect in the treatment of children with rotavirus enteritis，and with less adverse reaction. 　　[Key words] Rotavirus； Enterits； Children； Lactoferrin 　　自1973年澳大利亚学者Bishop等首次发现轮状病毒（rotavirus，RV）以来，人们对RV研究越来越深入。据世界卫生组织2008年统计，RV感染造成45.3万（42.0万～49.4万）幼童死亡，在发展中国家，小儿腹泻常是婴幼儿死亡的主要原因，仅次于肺炎，居第二位[1]。大约90%的RV感染相关死亡病例发生在亚洲和非洲的发展中国家[2]