伏立康唑治疗儿童白血病侵袭性肺部真菌感染疗效剖析.docVIP

伏立康唑治疗儿童白血病侵袭性肺部真菌感染疗效剖析 　　[摘要] 目的 探讨伏立康唑治疗儿童白血病侵袭性肺部真菌感染的临床效果，对临床抗真菌感染用药的选择进行指导。方法整群选取2011年10月―2013年10月在该院血液内科接受白血病侵袭性肺部真菌感染治疗的患儿128例为研究对象，随机分为两组，各64例，观察组患者采取伏立康唑治疗，对照组患者给予氟康唑治疗，两组患者的治疗有效率和真菌清除率进行观察比较。结果 观察组患者治疗有效率及真菌清除率均高于对照组，两组数据差异有统计学意义（P0.05）。结论 对于儿童白血病侵袭性肺部真菌感染，给予伏立康唑治疗效果明显优于给予氟康唑治疗。伏立康唑可以提高治疗的有效率以及真菌的清除率，具有较高的安全性，用于治疗儿童白血病侵袭性肺部真菌感染疗效较好；因此，值得在临床中推广及使用。 　　[关键词] 立康唑；儿童白血病；侵袭性肺部感染；真菌感染；疗效分析 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2015）05（b）-0112-02 　　Voriconazole Treatment of Childhood Leukemia Analyze the Effect of Invasive Pulmonary Fungal Infections 　　ZHENG Li 　　Pediatric Department of Hematology Nanyang Central Hospital， Nanyang， Henan Province， 473000 China 　　[Abstract] Objective To investigate the clinical effect of voriconazole in the treatment of leukemia in children with invasive pulmonary fungal infections， to guide the clinical anti fungal drugs of choice. Methods From 2011 October to 2013 October to accept invasive pulmonary fungal infection in children with leukemia treatment of128 patients as the research object in the Department of internal medicine in our hospital to take blood， voriconazole treatment， patients were observed the effective rate of the treatment and fungal clearance rate.Results In this experimental research， patient treatment efficiency was 93.8%； after treatment of fungal clearance rate was 84.4%， the occurrence of mild liver damage， gastrointestinal reactions and abnormal vision and other adverse reactions only a minority of patients， but with mild adverse reactions.Conclusion Voriconazole can improve the treatment efficiency and fungal clearance rate， high security， for the treatment of leukemia in children with invasive pulmonary fungal infection， good curative effect， is worth the clinical promotion. 　　[Key words] Voriconazole； Childhood Leukemia； Invasive pulmonary fungal infections； Fungal Infections； Analysis of clinical effect 　　儿童白血病患儿的机体防御、造血功能以及免疫力都会有明显的下降，在长期对白血病患儿实施治疗的过程中，随着激素以及化疗等多种药物的联合使用，儿童白血病患者真菌感染的数量有一定