TT检测在宫颈癌筛查及临床分期效能分析.docVIP

TCT检测在宫颈癌筛查及临床分期效能分析 胡淑玲呼伦贝尔市妇幼保健所(内蒙古呼伦贝尔021008) 】目的分析探讨液基细胞学检测(TCT)检测在宫颈癌筛查及临床分期 的诊断效能及临床意义。方法对我院2011年3月至2012年6月150例根据临 床症状疑是宫颈癌或上皮内瘤变患者进行TCT筛查及临床分期相关性分析，确诊 以阴道镜下宫颈组织病理活检为金标准。结果TCT诊断宫颈癌特异性为0.704, 敏感性为0.886，一致率86.00% , ROC特征曲线下面积分别为0.884 (95% CI： 0.830-0.939) ,P=0.000；不同临床分期诊断效能无统计学差异(TCT阳性结果界 定值ge;非典型鳞状上皮)，而各临床分期TCT检测分级结果chi; 2=16.717, P=0.001lt;0.05,差异存在统计学意义。结论液基细胞学检测(TCT)诊断宫颈癌 效能显著，且各临床分期诊断效能无显著统计学差异，其有早期筛查及临床确诊 等优点，值得临床推广。 关键词】液基细胞学检测；宫颈癌；临床分期 ［ ］R329.2 ［ ］A ［ ］1810 — 5734(2013)03— 一 TCT detection performance analysis in cervical cancer screening and clinical staging ? Hu shu Ling themetrnity and child health care Hucun beier in Neimeng Gu 021008 Abstract】 Objective To analyze the clinical significance and different clinical stage effectiveness in cervical cancer screening and diagnosis of liquid-based cytology test (TCT) detection. Method Hospital from March 2011 to June 2012,150 cases of suspected based on clinical symptoms of cervical cancer or intraepithelial neoplasia patients with TCT testing，diagnosed colposcopic cervical biopsy as the gold standard. Result TCT diagnosis of cervical cancer possessed a specificity of 0.704, a sensitivity of 0.886, the same rate of 86.00%,and the ROC characteristic area under the curve were 0.884 (95% Cl :0.830-0 .939),P=0.000. No significant difference in the diagnostic effectiveness of different clinical stages （TCT positive results defined value ge;ASCUS）,while clinical stage TCT detection classification resultedchi; 2 = 16.717, P = 0.001 lt;0.05, differences statistically significant.Conclusion TCT diagnosed of cervical cancer performance significantly,without significant statistical difference in different clinical stage,and possessed an advantages of early screening and clinical diagnosis,worthiing popularizing. Key Words］ Liquid-based cytology test; cervical cancer; clinical stage 宫颈癌作为妇产科常见恶性肿瘤疾病，好发于各阶段育龄期妇女，发病 率及死亡率仅分别次于乳腺癌和肺癌［1, 2］。近年来，随着细胞学及影像学 筛查技术的推广和普及，发病率明显降低，但据不完全统计显示，每年全世界范 围内仍有50万新发及24万死亡病例报道［3］。因此，宫