SBRT治疗肺癌新机遇和挑战.pptx

SBRT治疗肺癌新机遇和挑战;SABR或SBRT（ASTRO和ACR）的定义： SABR(Stereotactic ablative radiotherapy) SBRT(Stereotactic Body Radiation Therapy) 采用外照射技术，分1到数次，将放射治疗的高剂量精确投照到颅外体部肿瘤病灶上,从而使肿瘤受到高剂量和肿瘤周围正常组织受到低剂量照射的一种特殊放疗技术。;SBRT实现的方式;SBRT在早期NSCLC治疗中地位： 1）可以作为不能手术或拒绝手术患者标准治疗 （Radiotherapy and Oncology 2010 94 1–11） （JAMA 2010 303:1070） 2）可以作为临界手术者楔形切除外的另一选择 （JCO 2010 20;28(6):928-35 ） (Chest. 2012 Dec;142(6):1620-35) (J Thorac Cardiovasc Surg 2012 Sep;144(3):S35-8) 3）在可手术患者价值尚待临床III期试验 （IJROBP 2011 81 1352-8） （IJROBP 2012 83 348-53） 4)SBRT治疗中央型肺癌是安全有效的 (RTOG0813) (Radiotherapy and Oncology 2013 106 276–282) 5) SBRT的技术建立需要依据各中心的条件而建立 ;SBRT对患者内科条件要求;SBRT对患者内科条件要求;Outcomes of stereotactic ablative radiotherapy for central lung tumours: A systematic review;;;Chest 1994 106 320S-3S ;SBRT-based treatment model for stage I medically inoperable SCLC;Clinical results of SBRT for Stage I SCLC: a single institutional experience;分期的准确性;Treatment of multiple primary lung cancers using SABR, either with or without surgery;Treatment of early-stage lung cancer detected by screening: surgery or stereotactic ablative radiotherapy?;Management of multiple pure GGO lesions in patients with bronchioloalveolar carcinoma;A Dominant Adenocarcinoma With Multifocal GGO Does Not Behave as Advanced Disease;Natural History of Pure GGO Lung Nodules Detected by Low-Dose CT Scan;Meta-analysis of CT-Guided Transthoracic Needle Biopsy for the Evaluation of GGO Pulmonary Lesions;SBRT Can Be Used Safely to Boost Residual Disease in Locally Advanced NSCLC: A Prospective Study;Dose escalation with SBRTlocally advanced NSCLC;器官;SBRT for patients with lung cancer previously treated with thoracic radiation;SBRT as Salvage for Intrathoracic Recurrence in Patients With Previously Irradiated Locally Advanced NSCLC;SBRT for re-irradiation of persistent or recurrent NSCLC;Toxicity and outcomes of thoracic re-irradiation using SBRT;Salvage SBRT for Local Failure After Primary Lung SB