高血压伴腔隙性脑梗死患者危险因素关联性剖析.docVIP

高血压伴腔隙性脑梗死患者危险因素关联性剖析 　　【摘要】目的了解高血压病（PH）伴腔隙性脑梗死（LI）与慢性血管疾病高危因素的相关关系，为提高PH+LI的防治效果提供依据。方法随机抽取PH+LI患者472例（PH+LI组）和527例高血压病不伴脑梗死患者（PH组），检测身高、体重、空腹血糖（FBG）、血脂和血尿酸（UA），用Logistic分析比较两组资料高危因素的关联性。结果PH+LI组肥胖、糖尿病、高尿酸血症、胆固醇升高和甘油三酯升高的患病率较PH组高（P0.05）。Logistic分析表明，男性、肥胖、高尿酸血症和甘油三酯升高等是PH+LI患病的危险因素，患病风险分别是2.16、10.46、35.16和5.54倍。结论PH+LI与性别、体质、血脂、血尿酸等因素有关，男性、肥胖、高尿酸血症和甘油三酯升高是PH+LI患病的危险因素。 　　【关键词】腔隙性脑梗死；原发性高血压；血管疾病；危险因素 　　中图分类号：R743.3 文献标识码：ADOI：10.3969/j.issn2015.04.002 　　【Abstract】ObjectiveTo understand correlation of risk factors of hypertension（PH） combined with lacunar infarction（LI） and chronic cardiovascular disease，so as to provide reference for prevention and treatment of PH combined with LI.Methods472 cases of PH combined with LI were randomly selected as PH+LI group，and 527 cases of PH without LI as PH group.Then，heights，weights，fasting bloodglucose（FBG），blood lipid and blood uric acid（UA） of the two groups were detected.In addition，logistic regression analysis was used to compare the relationship of risk factors of data between the two groups.Results Prevalence rates of obesity，diabetes，hyperuricemia，elevated cholesterol and triglyceride of the PH + LI group were higher than those of the PH group（P0.05）.Logistic regression analysis showed that the risk factors of PH+LI were male， obesity，diabetes，hyperuricemia and increase of triglyceride，risk of disease were 2.16，10.46，35.16 and 5.54 times，respectively.ConclusionPH+LI is related to gender，body condition，blood lipid and UA，and its risk factors are male，obesity，diabetes，hyperuricemia and increase of triglyceride. 　　【Key words】lacunar infarction；primary hypertension；vascular disease；risk factors 　　腔隙性脑梗死（Lacunar Infarction，LI）是脑梗死（Cerebral infarction，CI）较常见的类型，占CI的20%～30%，90%的LI患者合并有原发性高血压（Primary hypertension，PH）[1]。近30年来，LI和PH的发病率及患病率不断攀升，严重影响居民的生命健康， LI与PH常在同一患者中发生，并与心肌梗死、脑卒中等血管事件的发生发展紧密相关，备受关注[2]。为了解高血压病伴腔隙性脑梗死（PH+LI）与慢性血管疾病高危因素的关系，为科学防治本病提供依据，笔者随机抽取住院治疗的472例PH+LI患者和527例高血压病不伴脑梗死（PH）患者，检测身高、体重、空腹血糖（FBG）、血