肝脏弥散加权成像临床应用价值初步分析-影像医学与核医学专业论文.docxVIP

肝脏弥散加权成像临床应用价值初步分析-影像医学与核医学专业论文.docx

  1. 1、本文档共71页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  5. 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  6. 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  7. 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  8. 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
肝脏弥散加权成像临床应用价值初步分析-影像医学与核医学专业论文

上海交通大学医学院 上海交通大学医学院 2002 级七年制硕士研究生学位论文 PAGE PAGE 4 The CLI NI CAL EVALUATI ON OF DI FFUSI ON WEI GHTED MR I MAGI NG I N LI VERS: PRELI MI NARYM STUDY ABSTRACT Purpose: This study was designed to find out the characteristic of diffusion weighted MRI (DWI) in normal persons and liver fibrosis patients through the DWI exams, and also to assess the clinical feasibility of evaluating liver fibrosis by measuring the apparent diffusion coefficients (ADCs) and ascertain the accuracy in staging of the liver fibrosis and cirrhosis (F0-F6). Materials and methods: 77 patients (mean age 29.27±6.62 years) with histological proven liver fibrosis by liver biopsy and 37 healthy controls (mean age 46.97±16.56 years) underwent liver diffusion-weighted imaging (24 liver fibrosis patients underwent DWI again one year later) with different b values: b=0, 200, 500, 1000s/mm2. ADCs, SNR and image quality of diffusion-weighted images were measured respectively. Result: (1)There was no statistical difference of the ADC values of normal liver in different ages or genders(p0.05). The ADC values of liver left lobe was obviously larger than that of right lobe, and the ADC values of liver right VII, VIII lobe was obviously larger than that of right V, VI lobe. The ADC values(10-3mm2/s) of normal liver were 2.36±0.14(range: 2.15 - 2.60,b=200 s/mm2), 1.59±0.10(1.48 - 2.37,b=500 s/mm2), 1.48±0.25(1.42 - 1.76,b=1000 s/mm2). (2)With the increase of fibrosis stage, the ADC values decreased;And there had negative correlation between fibrosis stages and ADC values. As b=500 and 1000s/mm2, the mean ADCs were significantly lower in advanced stage of liver fibrosis (F≥3) comparing with those of controls and early stage of liver fibrosis (p0.05), which could not be found as b=200s/mm2. For b=500 s/mm2, the ADC threshold for advanced liver fibrosis (F≥3) was 1.695 (10-3mm2/s) with an area under the receiver operating characteristic(ROC) curve of 0.888, a sensitivity of 77.8% and a specificity of 87.

文档评论(0)

peili2018 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档