肿瘤相关巨噬细胞极化的研究进展.pdfVIP

第25卷第11期 生命科学 Vol. 25, No. 11 2013年11月 Chinese Bulletin of Life Sciences Nov., 2013 文章编号：1004-0374(2013) 11-1105-04 肿瘤相关巨噬细胞极化的研究进展 曹春雨，王　清，王艳林* (三峡大学医学院分子生物学研究所，宜昌443002) 摘　要：肿瘤相关巨噬细胞是肿瘤组织局部浸润的巨噬细胞，在肿瘤组织微环境中，这些巨噬细胞发生 M2 M2 型极化，从而发挥免疫抑制效应，促进肿瘤增殖。而 型极化的肿瘤相关巨噬细胞也能够被再次诱导 M1 逆向极化形成具有抗肿瘤效应的 型肿瘤相关巨噬细胞，激发机体产生特异性抗肿瘤免疫应答。促进肿 瘤相关巨噬细胞M1 型极化由此成为当前抗肿瘤免疫防治研究的热点。将对有关肿瘤相关巨噬细胞极化的 新进展进行综述，为抗肿瘤免疫研究提供新的思路。 关键词：肿瘤相关巨噬细胞；巨噬细胞极化；抗肿瘤免疫 R730.3 A 中图分类号： 文献标志码 ： Advances in polarization of tumor-associated macrophage CAO Chun-Yu, WANG Qing, WANG Yan-Lin* (Institute of Molecular Biology, Medical College, China Three Gorges University, Yichang 443002, China) Abstract: Macrophages are an essential effector and regulator in host innate and adaptive immunity. Recent studies demonstrated that macrophages, within tumor tissue, referring to as tumor-associated macrophages, play an important role in tumor immune tolerance. In tumor microenvironment, the majority of tumor-associated macrophages are polarized to M2 macrophages which function as immunosuppressor and therefore promote tumorigenesis. Meanwhile, under stimulation of some specific factors, tumor-associated macrophages can be reversely polarized to M1 macrophages which can engulf tumor cells and boost anti-tumor immune response. How to promote tumor-associated macrophages M1 polarization in anti-tumor immune research has become a hot issue. Here, we reviewed the latest development in tumor-associated macrophages polarization research. Key words: tumor-associated macrophage; macrophage polarization; anti-