玻璃酸钠治疗膝关节骨性关节炎的疗效观察-医学信息.PDFVIP

床 研究 学信息2019 年1 月第32 卷第1 期 Medical Information Jan. 2019 Vol. 32 No.1 玻璃酸钠治疗膝关节骨性关节炎的疗效观察 懋宇 北京医院骨科袁北京 100730冤 摘要 目的 探讨玻璃酸钠治疗膝关节骨性关节炎的临床疗效遥 方法 选取2015 年10 月~2017 年10 月我院收治的膝关节骨性 关节炎患者90 例袁随机分为观察组和对照组袁各45 例遥对照组患者采用复方倍他米松治疗袁观察组在此基础上加用玻璃酸钠治 疗遥观察两组临床疗效及治疗前后炎性因子指标改变情况袁比较两组治疗前后骨关节功能评分尧VAS 评分尧膝关节HSS 评分袁记 录两组患者不良反应情况遥 结果 治疗后袁观察组总有效率为93.33%袁高于对照组的82.22%袁差异有统计学意义 0.05冤曰治疗 后袁两组患者骨关节功能评分尧VAS 评分尧膝关节HSS 评分 有所改善袁且观察组改善程度优于对照组袁差异有统计学意义 0.05冤曰治疗后袁两组患者IL-1 尧IL-6 水平 下降袁IL-10 水平 上升袁且观察组患者变化程度更加明显袁差异有统计学意义 0.05冤曰观察组患者不良反应发生率为6.67% 袁高于对照组的17.78%袁差异有统计学意义 0.05冤遥 结论 玻璃酸钠治疗膝关节骨 性关节炎临床疗效显著袁可改善患者骨关节评分和疼痛情况袁改善患者炎性因子指标袁且不良反应较少遥 关键词 玻璃酸钠曰膝骨关节炎曰复方倍他米松曰骨关节功能 中图分类号 R684.3 文献标识码 A DOI:10.3969/j .issn.1006-1959.2019.01.034 文章编号 1006-1959 2019冤01-0112-03 Therapeutic Effect of Sodium Hyaluronate on Knee Osteoarthritis ZHAO Mao-yu (Department of Orthopaedics,Beij ing Hospital,Beiji ng 100730,China) Abstract ：Obj ective To investigate the clinical efficacy of sodium hyaluronate in the treatment of knee osteoarthritis.Methods 90 patients with knee osteoarthritis admitted to our hospital from October 2015 to October 2017 were randomly divided into observation group and control group, with 45 cases in each group. The control group was treated with compound betamethasone, and the observation group was treated with sodium hyaluronate. The clinical efficacy and the changes of inflammatory factors were observed before and after treatment. The bone and j oint function scores, VAS scores and HSS scores of the knees were compared before and after treatment. The adverse reactions of the two groups were recorded.Results After treatment, the total effective rate of the observation group was 93.