降脂通脉饮治疗高脂血症的临床与实验研究-中西医结合内科学专业论文.docxVIP

、j与s意亨tl提要 、j与s意亨tl 提要 高脂靓症，是诱发老年人心、脑靓管疾病的堂溪的危险困索，是威胁老年人健 康及生命的常见疾病，镶者以中医理论为基础，通道临床观察、动物实验及锻阅大 量医学文献，提出努虚膊弱、纳运失键、浊瘀内生为本病的病因病枧，据此确立补 弩健薅、识澡降浊、活擞遥辣豹治疗方法，莠依攒诧法绥方“醛耱通黥饮”。壤者选 取58例高脂血症患者随机分为降脂通脉饮治疗组32例和脂必潞对照组26例，进行 观察治疗前厝临床症状和实验室化验指标的变化。动物实验选取30只大鼠喂饲高脂 锈瓣造戒褰爨盘症模登瑟，夔秘分为舞器缓、降§鹭逶藤蔹组巍鬻努妥缝各10只，鼹 察实验室指标的变化。络果降脂通脉饮组患者用药60天后，临床症状明显改蒋，血 清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—C)含量降低，而 盔密度脂蛩囱胆困醇(HDL—e)含量秀离。临床症状改善和降低盘骀斡作嗣均明显 侥子瑟必妥瓣造组(pO．05)。同时，治疗后惑者瓶浆丙二醛(MDA)、氧纯受低密度 脂蛋白(OX—LDL)含量明显降低，瓶超氧化物歧化酶(SOD)活性明显升高，其统 计学处理升高SOD活性的疗效明显优予对照组。动物实验研究袭明，该方剂舆育与 鏊寨握霉静貉鼹、抗氧毒艺、改善盘滚滚交学夔俘甏。本磅究证突了簿鬻逶踩饮具舂 补肾健脾、化湿降浊、活_血通脉的疗效，从中医基础理论及现代药理学研究遮两个 方面都证实了降脂通脉饮的临床疗效。 关键谰： 高§旨盘癍降耱通脉饮 中莲药疗法 箍床磷巍 实验研究 CI CI inicaI and ExperimentaI Study on Treating HyperI ipidemin of 0}d Age with the Jiang Zhi Tong Mai Decootion． Speciai ity：The study of Cardiovascutar器iseases．Internai Medioine of Integrated TraditionaI and Western tilediOime． Author：Yan瓣ui Tutor：Prof Guo Weixing Abstract It is terified that hyperl{pidemia and the diseases caused by it such as atherosclerosis，coronary heart disease，cerebralvascular disease and so on．are the kjnd of disease which threaten the 1ife and health of mankind seriously．For the sake of observing the cl inical effect of jiang Zhi Tong Mai Decoction (JZTMD) and exploring its therapeutic mechanism on hyperiipidemia,Fifty--eight Cases of patients with hyperlipidemin were selected and divided randomlY into JZTMD group(32 cases)and control group (26 cases)+The pati ents in JZTMD group and conteol group were treated with JZTMD and Zhi Bi Tuo(ZBT)respectively．The changes of clinical symptoms and laboratory indexes in al l the patients were observed before and after treatment．Meanwhile，thirty rats with hyperlipidemin were selected and divided random]Y into JZTMD group(io rats)，control group《i0 rats)and model group(10 rats)．The thirty rats were fed with high fat diet．Afterwards， we divided randomly the rats of high fat into three groups，namety high fat diet group(10 rats)，JZTMC group(10 rats)and