角膜穿孔伤对环丙沙星眼内渗透性影响的实验研究-眼科学专业论文.docxVIP

角膜穿孔伤剥环丙沙星眼内渗透性影响的实验研究 角膜穿孔伤剥环丙沙星眼内渗透性影响的实验研究 中山大学硕士学位沦文 ug／mlvs(O．072+0．034)ug／ml，两者无显著性差异(P0．05)。 结沦： l、角膜穿孔伤可以影响血一房水屏障，使其通透性增加； 2、角膜穿孔伤后静脉注射环丙沙星，房水中环丙沙星的水平明显 提高； 3、静脉用环丙沙星房水中浓度显著高于大部分眼内致病菌90％菌 株最小抑菌浓度(MIC90s)； 4、角膜穿孔伤静脉用环丙沙星后房水中药物浓度与血一房水屏障的 改变密切相关； 5、角膜穿孔伤时静脉注射环丙沙星，玻璃体中的水平很低，要使 玻璃体中达到较高的药物浓度，玻璃体腔注射抗菌药或玻璃体切割是 需要的。 关键词：角膜穿孔伤血．眼屏障环丙沙星眼内渗透性 角膜穿孔伤对环丙沙星眼内渗透性影响的实验研究 角膜穿孔伤对环丙沙星眼内渗透性影响的实验研究 中山大学硕士学位论文 The effect of penetrating cornea inj ury on the ocular penetrace of intravenous ciprofloxacin。 Major：Ophthalmology Postgraduate：Bei Zhou Supervisor：Prof．Xiaofeng Lin Abstract Purpose： Bacterial endophthalmitis is a devastating complication after ocular su唱ery and trauma，which will progress to panophthalmitis and impairment of visual acuity without prompt and suitable antibiotic therapy．Few antibiotics via intravenous injection can penetrate the blood—ocular barrier and reach MIC90 in aqueous or vitreous cavity in normal eyes．However,it is still not known the permeability of antibiotics to aqueous or vitreous cavity after penetrating corneal trauma that results in impairment of blood·ocular barrier．In this study,we investigate the changes of blood—ocular barrier after penetrating comeal trauma and the intraocular permeability of ciprofloxacin via intravenous injection and fumish experimental data for administering antibiotices rationally in clinical． Method： Fifteen New Zealand albino rabbits were included in this study,right eyes were selected as experimental group and left eyes were selected as the control group．Ciprofloxacin intravenous injection(20mg／kg)Was III 角膜穿7L伤对环丙沙星眼内渗透性影响的实验研究 角膜穿7L伤对环丙沙星眼内渗透性影响的实验研究 中山大学硕士学位沦文 performed one hour after the penetrating corneal trauma model was established．Ciprofloxacin concentration of aqueous humor and vitreous body was measured 30 minutes after the intravenous injection by reversed phase high performance liquid chromatograph(RP—HPCL)and the protein concentration of aqueous humor was measured by biuret conorimetric metho