结直肠癌寡转移的概念及诊疗进展-肿瘤学专业论文.docxVIP

PAGE PAGE 10 结直肠癌寡转移的概念及诊疗进展 【摘要】结直肠癌是最常见的恶性肿瘤之一，根据世界卫生组织（world health organization, WHO）报道，结直肠癌是男性第二位和女性第三位常见的恶性 肿瘤。2012年全球男性结直肠癌新发病例为746000例，占所有恶性肿瘤10%；女性 结直肠癌新发病例为614000例，占所有恶性肿瘤9.2%。在我国大肠癌是常见的同 时也是备受关注的恶性肿瘤之一，并且近年来发病率和死亡率有逐年上升趋势。 复发和转移是大肠癌预后不佳的主要因素，其常见转移部位为肝、肾以及骨骼系 统。 20 世纪 90 年 代 ， Hellman 与 Weichsel-baum 共 同 提 出 了 “ 寡 转 移 ” （oligometastatic）的概念。寡转移是一种状态，是指肿瘤生物侵袭性较温和的一 段时期，它存在于局限性原发灶与广泛性转移之间的过渡阶段，转移瘤的数量有 限并且转移的器官具有特异性。不仅见于结直肠癌而且还 见于非小细胞肺癌 （non-small cell lung carcinoma，NSCLC）、乳腺癌、骨与软组织肉瘤等。 多学科协作治疗（multidisciplinary team treatment ,MDT）是根据患者的身心状 态、肿瘤的具体部位、病理类型、侵犯范围（病期）和发展趋势，结合细胞、分 子生物学改变，有计划的、合理的应用现有的多学科治疗手段，以最适当的经济 费用取得最好的治疗效果，同时最大限度的改善患者的生活质量和生存时间。 【关键词】 结直肠癌 寡转移 多学科协作治疗 进展 The Concept Of Colorectal Cancer Oligometastatic and Diagnosis and Treatment Progress 【Abstract】 Colorectal cancer is one of the most common malignant tumors. According to World Health Organization (WHO) reports, colorectal cancer is the third and the second most common malignant neoplasms in the males and females respectively. In 2012, the worlds new cases of colorectal cancer for men are 746,000 cases which accounting for 10% percent of all malignant tumors and women are 614,000 cases which accounting for 9.2% percent of all malignant tumors. In our country the colorectal cancer is one of the most common malignant tumorsas well as the concern for malignancy, and in recent years the incidence rate and mortality rate increased year by year. Recurrence and metastasis are the main factors of poor prognosis in the colorectal cancer, whose the common metastatic sites are liver, kidney and skeletal system. In the 1990s, Hellman and Weichsel-baum put forward the concept of Oligometastatic together. Oligometastatic is a state which refers to a milder period of the tumor biological invasion. Oligometastatic exists in the transition stage between limitation primary tumor and extensive metastasis, which has a limited numbr of the metastatic tumor and the specific metastatic organ. Oligometastati