麻杏止咳平喘颗粒剂成型工艺研究-天津中草药杂志社.PDF

中草药 Chinese Traditional and Herbal Drugs 第47 卷 第5 期 2016 年3 月 ·767 · 麻杏止咳平喘颗粒剂成型工艺研究 1, 2 2 2, 3 2 2* 那溪元 ，刘 毅 ，殷明阳 ，刘素香 ，陈常青 1. 哈尔滨商业大学药学院，黑龙江 哈尔滨 150076 2. 天津药物研究院，天津 300193 3. 天津中医药大学，天津 300193 摘 要：目的 优选麻杏止咳平喘颗粒剂的成型工艺。方法 考察不同辅料糊精、糖粉、可溶性淀粉用量对浸膏粉吸湿性的 影响，用正交试验法优选制粒工艺条件，考察颗粒的流动性与吸湿性，以成型率、溶解性及吸湿率为指标，筛选处方中加入 辅料的品种、配比及最佳成型工艺。结果 以糖粉加糊精作辅料的颗粒优于以糊精或糖粉或可溶性淀粉作辅料的颗粒，最佳 工艺条件为主药-辅料（1 ∶2 ）、辅料配比为糊精-糖粉（1 ∶1），以80%乙醇为润湿剂，润湿剂的用量占主药的14%。结论 该 颗粒剂所选辅料合理，成型制备工艺可行，本研究为麻杏止咳平喘颗粒制粒工艺条件的确定及生产环境的控制提供了科学的 实验依据。 关键词：麻杏止咳平喘颗粒；正交试验；成型性；溶解性；相对临界湿度；成型工艺 中图分类号：R284.2 文献标志码：A 文章编号：0253 - 2670(2016)05 - 0767 - 04 DOI: 10.7501/j.issn.0253-2670.2016.05.013 Study on forming technique of Maxing Antitussive and Antiasthmatic Grannule 1, 2 2 2, 3 2 2 NA Xi-yuan , LIU Yi , YIN Ming-yang , LIU Su-xiang , CHEN Chang-qing 1. College of Pharmacy, Harbin University of Commerce, Harbin 150076, China 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 3. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: Objective To optimize the processing conditions of Maxing Antitussive and Antiasthmatic Grannule (MAAG). Methods The influence of different excipients including lactose, soluble amylum, and dextrine, and usage amount of soluble amylum to hygroscopicity of powdered extract was investigated; Processing conditions were optimized by orthogonal test, flowability, and hygroscopicity were investigated. Taking forming rate, solubility, and absorption rate as indexes, the materials added prescription varieties, ratio, and optimum molding process were screened. Results The particles sugar plus dextrin as excipients were superior