大黄酚聚氰基丙烯酸丁酯纳米囊的制备工艺及质量研究.PDF

中草药 Chinese Traditional and Herbal Drugs 41 4 2010 4 54 * 黄红娜, 张丹参,郑晓霞, 张 力 ,薛贵平 ( , 075000) : , , 4 , , L (3 ) pH 9 -, 5 mg , : 800 r/ min, pH 2,- 13 L, 06 mL 8219%, 2148%, 246 nm, ,, , , :; ; :R2842 :A : 0253-2670( 2010)04-0547-04 Preparation of chrysophanol loaded polybutylcyanoacrylate nanocapsules and its quality inspection HUAN Hong-na, ZHAN Dan-shen, ZHEN Xiao-xia, ZHAN Li, XUE u-i ping ( Department of Pharmacology, Hebei North University, Zhangjiakou 075000, China) Abstract: Objective T o optimize the preparation technology of chrysophanol loaded polybutylcyano- acrylate nanocapsules by interfacial polymerization, sieve the optimal technology conditions of preparation, and study its quality Methods Based on the single factor experiment, the formulation was optimized by 4 L9 ( 3 ) orthogonal design with entrapment efficiency as reference index The factors including agitating speed, pH value of aqueous phase, amount of -butylcyanoacrylate ( BCA) and of ethyl acetate were screened At last, its shape, particle size, the encapsulation efficiency, and the drug loading were invest-i gated as its quality inspection Results When the ammunt of chrysophanol was 5 mg, the optimum prepa- ration conditions were established as follows: the agitating speed was 800 r/ min, thepH value of aqueous phase was 2, the amount of -BCA was 13 L and ethyl acetate was 06 mL Under this optimum cond-i tion, the mean entrapment ratio was 8219% , and themean drug loading was 2148% , the mean diamet