2019年药师林育成.pptVIP

Hepatitis B vaccine (1)商品名:ENGERIX-B 安在時 DESCRIPTION Engerix-B is a noninfectious recombinant DNA hepatitis B vaccine. The vaccine is derived from hepatitis B surface antigen (HBsAg) produced through recombinaaant DNA techniques from yeast cells, Saccharomyces cerevisiae. The portion of the hepatitis B gene which codes for HBsAg is cloned into yeast which is then cultured to produce hepatitis B antigen Hepatitis B vaccine (2)商品名:ENGERIX-B 安在時 CLINICAL PHARMACOLOGY : Hepatitis B infection會造成嚴重的acute massive hepatic necrosis, chronic active hepatitis and cirrhosis of the liver.這些病人會變成慢性帶原者而感染其他人及增加發展 primary hepatocellular carcinoma的機會. 小孩於小於5歲前感染有特別高的危險性發展成慢性帶原. 因為D型肝炎需存在於B型肝炎感染的狀況下,所以施打此疫苗亦可防止D型肝炎的感染. Hepatitis B vaccine (3)商品名:ENGERIX-B 安在時 USAGE:採肌肉注射.HBsAg+母親的小孩於出生12小時內接受hepatitis immunoglobulin(HBIG)0.5ml,並於第1-2個月及第6個月接受疫苗.若母親的HBsAg狀態不確定,嬰兒應在12小時內接受疫苗,若母親發現為:HBsAg+,應盡快給予HBIG. Booster vaccinations: ?? For healthy vaccine recipients, protection persists for 5 years or longer in most cases. 10 mcg for children 10 years of age and under 20 mcg for adolescents 11 through 19 years of age 20 mcg for adults. 透析病人或免疫不全者若第3劑施打2個月後anti-HBs level10mLU/ml,則需再追加第4劑. 早產兒應如同足月兒般正常時間接受預防注射 CONTRAINDICATIONS Hypersensitivity to any part of the vaccine Hypersensitivity to yeast, although no adverse effects have been published Immunosuppressive therapy:leukemia,lymphoma,congenital or acquired immunodeficiency disorders… PREGNANCY CATEGORY C POLIO (1) DESCRIPTION:1999年Immunization Practices Advisory Committee (ACIP)建議使用all-IPV schedule,因為wild poliovirus的威脅性下降,而相對的OPV所導致的vaccine-associated paralytic polio (VAPP)危險性卻較令人無法忍受. USAGE:4 dose of IPV : 2, 4, 6-18個月, and 4-6歲 OPV只建議使用於下列狀況: 1)為控制爆發的大流行 2)小孩旅行於流行地 3)父母拒絕使用IPV(可建議此類小孩接受頭兩次的 IPV注射,接下來兩次再使用OPV.) POLIO (2) DIPHTHERIA, TETANUS, ACELLULAR PERTUSSIS VACCINE (DTaP ) (2) DESCRIPTION 包括 Bordetella Petussis 4種antigen( pertussis t