2019年AHA科学声明：心肾综合征的分类，病理生理学，诊断和治疗策略.pdf

Circulation AHA SCIENTIFIC STATEMENT Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies A Scientific Statement From the American Heart Association ABSTRACT: Cardiorenal syndrome encompasses a spectrum of Janani Rangaswami, MD, disorders involving both the heart and kidneys in which acute or Vice Chair chronic dysfunction in 1 organ may induce acute or chronic dysfunction Vivek Bhalla, MD, FAHA in the other organ. It represents the confluence of heart-kidney John E.A. Blair, MD interactions across several interfaces. These include the hemodynamic Tara I. Chang, MD, MS cross-talk between the failing heart and the response of the kidneys Salvatore Costa, MD and vice versa, as well as alterations in neurohormonal markers Krista L. Lentine, MD, PhD and inflammatory molecular signatures characteristic of its clinical Edgar V. Lerma, MD, FAHA phenotypes. The mission of this scientific statement is to describe the Kenechukwu Mezue, MD, MSc epidemiology and pathogenesis of cardiorenal syndrome in the context Mark Molitch, MD of the continuously evolving nature of its clinicopathological description Wilfried Mullens, MD, over the past decade. It also describes diagnostic and therapeutic D