冠心病患者心肌灌注与心肌功能临床应用-影像医学与核医学专业论文.docxVIP

华中科技大学博士学位论文 华 中 科 技 大 学 博 士 学 位 论 文 - PAGE 6 - PAGE 6 ABSTRACT Evaluation of myocardial perfusion and systolic function in patients with coronary artery disease by myocardial contrast echocardiography and two-dimensional strain echocardiography PART Ⅰ Evaluation of the impact of the degree of coronary artery stenosis on myocardial perfusion by real-time myocardial contrast echocardiography Objective We attempted to evaluate the impact of the degree of coronary artery stenosis of coronary artery patients on myocardial perfusion by real-time myocardial contrast echocardiography (MCE). Methods 40 patients underwent intravenous real-time MCE after venous injections of Sono Vue. Left ventricular wall was divided into 18 segments and quantitative analysis was performed by Q-analysis software. Results (1) There were 507 segments subtended by coronary arteries with ＞50% stenosis, including 114 segments with abnormal wall motion and 393 segments without abnormal wall motion. A, k and the product A×k were significantly lower in segments with abnormal wall motion than those without abnormal wall motion [ (6.07±3.16) dB vs (7.20±3.11) dB, P＜ 0.01；(0.25±0.11)/s vs (0.31±0.16) /s, P＜0.01；(1.57±1.25) dB/s vs (2.28±1.16) dB/s， P＜0.01＝＝. However, the standardized number of the product A×k was significantly lower in segments with abnormal wall motion than those without abnormal wall motion [(0.13±0.10) vs (0.19±0.16), P＜0.01＝. (2) Segments with normal wall motion were divided into 2 groups. Group 1 had 279 segments whose flow was subtended by coronary arteries with ≥75% stenosis. Group 2 had 114 segments whose flow was subtended by coronary arteries with ＜75% stenosis. The product A×k in group 1 was lower than that in group 2[ (2.14±1.46) dB/s vs (2.62±2.02) dB/s, P＜0.01]. At the same time, the standardized number of the product A×k in group 1 was lower than that in group 2[(0.17±0.11) vs (0.23±0.15), P＜ 0.05＝. Conclusions Our present study showed that the produc