基于ACO-SVM的质谱数据分析.PDF

36 4 2010 2 Vol.36 No.4 Computer Engineering February 2010 ·· 2010 A TP18 ACO-SVM 1,2 1 (1. 2141222. 214101) 94%92.4% Analysis of Mass Spectral Data Based on ACO-SVM ZHANG Rong1,2, FENG Bin1 (1. School of Information Technology, Jiangnan University, Wuxi 214122; 2. Department of Computer Engineering, Jiangsu College of Information Technology, Wuxi 214101) AbstractThe high dimensional and small sample sizes natures of bioinformatics pose a great challenge for many modeling problems. A novel method is raised that combines using SNR as prior information in the Ant Colony Optimization(ACO) searching process. Combined with support vector machines, it is applied to identify relevant serum proteomic biomarkers. Experimental results show that the proposed method has strong power in distinguishing cancer patients from healthy individuals, and yields up to 94% sensitivity and 92.4% specificity. Key wordsSurface-Enhanced Laster Desorption/Ionization Time-Of-Flight Mass Spectrometry(SELDI-TOF-MS); proteomics; Ant Colony Optimization(ACO) algorithm; feature selection technology; biomarker 1 (clinical proteomics) (Surface-Enhanced Laster Desorption/Ionization Time-Of-Flight 3 Mass Spectrometry, SELDI-TOF-MS) 3.1