基于VCTDSA数据的颅内动脉瘤模型流固耦合分析-SemanticScholar.PDFVIP

　 军 杂 2014年11月1 日　第39卷　第11期 888 解放 医学 志　 论　著 基于VCTDSA数据的颅内动脉瘤模型流固耦合分析 刘丹，曾鸣，张翱，向波，李晓燕，吕发金 [摘要]　目的　探讨血流动力学因素在颅内动脉瘤的发病机制与发展过程中的作用。方法　以颅内动脉瘤患者的 容积CT数字减影血管造影数据为基础，利用Mimics 10.0软件进行三维重建与分割，得到颅内动脉瘤的真实三维形态模 型，再将模型引入ANSYS 14.0 ，依据人体生理数据构建血管壁模型，利用有限元法对颅内动脉瘤流体模型与血管壁模 型进行流固耦合分析计算。结果　在整个心动周期内，动脉瘤腔内均存在明显的恒定类型漩涡流动，动脉瘤顶部存在 低切应力区域，瘤颈部存在高切应力区域，动脉瘤顶部、体部及颈部分别存在较大变形和Von Mises应力分布区域。结 论　通过流固耦合的数值模拟方法探索动脉瘤内血液流动特性与瘤壁生物力学性能，可推测其易破裂的可能区域，进 行破裂风险评估，为深入研究颅内动脉瘤的血流动力学提供技术支持。 [关键词]　颅内动脉瘤；血流动力学；流固耦合；壁面切应力；计算流体力学 [中图分类号]　R318.01　　　　[文献标志码]　A　　　　[文章编号]　0577-7402(2014)11-0888-05 [DOI]　10.11855/j.issn.0577-7402.2014.11.09 The fluid-structure interaction analysis of intracranial aneurysm model based on volume CT digital subtraction angiography 1 2 1 1 1 3* LIU Dan , ZENG Ming , ZHANG A o , XIANG Bo , LI Xiao-yan , LV Fa-jin 1Department of R adiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China 2Department of R espiratory M edicine, 3Department of R adiology, First Affiliated Hospital of Chongqing M edical University, Chongqing 400016, China * Corresponding author, E-mail: f ajinlv@163. com This work was supported by the Medical Scientific R esearch Projects of Health Bureau of Chongqing(2009-2-315, 2010-2-444) [Abstract]　Objective　To explore the effect of hemodynamic factors on the pathogenesis and development of intracranial aneurysms. The fluid-structure interaction (FSI) between blood and vessel wall would be considered in the process. Methods　 Based on the data of volume CT digital subtraction angiography (VCTDSA) in a patient with intracranial aneurysms, a true 3D model of intracranial aneurysms was obtained by 3D reconstruction and segmentation in the Mimics 10.0 software. The model was induced into ANSYS 14.0 software, and the vessel wall model was constru