哌拉西林舒巴坦治疗慢性阻塞性肺病患者重症肺部感染的疗效评价.docVIP

［派拉西林舒巴坦治疗慢性阻塞性肺病患者重症肺部感染的疗效评价 【摘要】目的评价哌拉西林舒巴坦静脉注射治 疗慢性阻塞性肺病患者重症肺部感染的临床疗效和安 全性。方法2010年6月?2011年6月我院住院确诊 慢性阻塞性肺病（Chronic Obstructive Pulmonary Disease, COPD）的重症肺部感染老年患者60例随机 分为哌拉西林舒巴坦治疗组（n=30例）和头孢匹胺对 照组（n=30例）。治疗组用0.9%生理盐水100ml+哌拉 西林舒巴坦2.5 g，静脉滴注，每天2次;对照组用0.9% 生理盐水100ml+头孢匹胺2.0g，静脉滴注，每天2 次，疗程7?14天。结果治疗前后对患者的体温、症 状、体征、胸片、白细胞计数检查、细菌学检查结果 对比，治疗组与对照组有效率分别为90%和56.6%。 哌拉西林舒巴坦组明显高于头孢匹胺组，有效率差异 有统计学意义（P 【关键词】哌拉西林舒巴坦头孢匹胺慢性阻塞 性肺病老年重症肺部感染 中图分类号：R563文献标识码：A文章编号: 1005-0515 （2012） 1-006-02 The evaluate of patients with severe pulmonary infection in chronic obstructive pulmonary disease by piperacillin and sulbactam JIA Feifei ZHANGhun The revolutionary disabled hospital of Sichuan province 【Abstract】 Objective To evaluate the curative effect and safety of intravenous injection piperacillin and sulbactam in treating chronic obstructive pulmonary disease(COPD) patients with severe pulmonary infection. Methods 60 patients with COPD from June 2010 to June 2011 were randomly divided treatment group(n=30, using Pipemeillin and Sulbactam)，and control group(n=30，using Cefpiramide). Patients in the treatment group were injected with physiological saline(100 ml)and piperacillin/suibactam (2.5g), twice every day. Meanwhile, the patients in the control group were injected with ceftazidime (2.0g)，physiological saline(100 ml)，once in 12 hours. The period of treatment was 7 — 14 days. Results Before and after treatment, comparing with the patients’ temperature, symptoms, signs, chest, white blood cell count check, bacteriological examination results, the curative efficiency for the treatment group and the control group were 90% and 56.6% respectively. It showed that the curative efficiency of treatment group was obviously higher than the control group. This is obviously difference of curative efficiency was significant in statistics （P0.05）。 1.2方法治疗组：给予哌拉西林舒巴坦（商品名： 力可多，四川制药制剂有限公司）2.5g，静脉滴注， 每天2次，疗程7?14天。对照组：给予头孢匹胺（商 品名：泰适，海南美好西林生物制药有限公司）2.0 g， 静脉滴注，每天2次，疗程7?14天，治疗中不联合 使用其他抗生素。同时治疗前后采取下呼吸道痰液标 本培养