2019CFAS临床实践指南：辅助生殖中子宫内膜薄的管理.pdf

1 RBMO VOLUME 00 ISSUE 0 2019 REVIEW Management of thin endometrium in assisted reproduction: a clinical practice guideline from the Canadian Fertility and Andrology Society (CFAS) BIOGRAPHY Dr Kimberly Liu is an infertility specialist practising at Mount Sinai Fertility, Toronto, Canada, and an Assistant Professor at the University of Toronto. She is the Program Director for the University of Toronto Gynecologic Reproductive Endocrinology and Infertility Fellowship Program. She is the author of numerous research publications and several national guidelines for fertility and ART practice in Canada. 1, 2 3, Kimberly E. Liu *, Michael Hartman , Alex Hartman KEY MESSAGE Thin endometrium is commonly encountered in patients undergoing assisted reproduction. Endometrial thickness may impact pregnancy and live birth rates in fresh and frozen IVF cycles. There is insuffcient evidence for the use of any adjuvants to increase pregnancy or live birth rates in patients with thin endometrium. ABSTRACT The impact and management of thin endometrium is a common challenge for patients undergoing assisted reproduction. The objective of this CFAS guideline is to provide evidence-based recommendations using the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) framework on the assessment, impact and management of thin endometrium in assisted reproduction. The effect of endometrial thickness on pregnancy and live birth outcomes in ovarian stimulation and IVF (fresh and frozen cycles) is addressed. In addition, recommendations on the use of adjuvants to improve endometrial thickness and pregnancy outcomes are provided. 1 Mount Sinai Fe