螺内酯治疗难治性高血压随机对照试验的meta分析-内科学专业毕业论文.docxVIP

Meta—analysis Meta—analysis of randomized controlled trials of spironolactone in treatment-resistant hypertension Abstract：objectiVe：To investigate the antihypertensive effect of spironolact— one of resistant hypertension and its effects on serum potassium of patients by searching the randomized controlled trials and conducting a meta—analysis． Methods：Searched in the Embase，Cochrane，Pubmed，and CNKI databases using two methods，including Medical Subject Heading(MeSH)terms and keywords terms，such as the following keywords： (“hypertension”and (‘‘resistant to conventional’’or‘‘resistant’’or‘‘drug resistant’’))and (spironolactone’’or‘‘verosipone’’or‘‘SC 9420’’)，and searched the conference papers and included studies’conferences by hand．Randomized controlled trials which explore the antihypertensive effect of spironolactone of resistant hypertension patients would brought into our meta—analysis；and excluded case reports，animal experiments，duplicated publications，reviews and abstracts；two researchers reviewed all the articles and used the Jadad standards to evaluated the quality of studies independently；if a discrepancy was noted，we discussed to make a decision or decided by third one；data related to this study were extracted according to data extraction table；data were summarized by Review Manager 5．3 and Stata 12．0 software．Q test and 12 statistic were used to detect the heterogeneity(we set P=0．1 and 12=50％as the statistically significant data)；we used fix·-effect model or random--effect model to calculate combined ．3． 万方数据 effect effect and 95％CI；we made sensitivity analysis by taking out a paper every time to analyze the effect of each study for the total effect，and found out the source of heterogeneity．The funnel plot and Egger test were used to evaluated the degree of publication bias．Results：There were 1 86 studies in total，and 42 come from Cochrane，76 come from Embase，5 8 come from Pubmed and the rest 1 0 come from CNKI；of those，6 studies met the eligibility c