抗多药耐药靶点及相关药物的研究进展_吴晨.pdf

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抗多药耐药靶点及相关药物的研究进展_吴晨.pdf

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PROGRESS IN PHARMACEUTICAL SCIENCES 2014,3388 11 :829-840 829 Research Progress in Therapeutic Targets for Multidrug Resistance and Related Drugs WU Chen, XU Zhuxuan, ZHOU Qimeng, ZHI Yunbao, LIN Kejiang ( Department of Pharmacy, China Pharmaceutical University, Nanjing 210009, China) Multidrug resistance (MDR) refers to the process in which cells produce wide resistance to a variety of drugs, leading to unsatisﬁ ed treatment. Multidrug resistance mainly occurs in treatment of infections and cancers, which greatly restricts the therapeutic effects on both diseases. The research progress of anti-MDR mechanisms and drugs based on the receptor types, including transport proteins, ion channels, enzymes and ribosomes, has been reviewed in this paper, so as to provide references for the development of anti-MDR drugs. multidrug resistance; infection; tumor; transporter; enzyme; ribosome protein