慢性阻塞性肺病急性加重期患者纤维蛋白原、血浆D-二聚体检测的临床意义-内科学(血液病学)专业毕业论文.docxVIP

万方数据 万方数据 目 录 一、中文摘要····················································3 二、英文摘要····················································4 三、引言························································5 四、研究对象与方法··············································6 五、研究结果····················································8 六、讨论························································9 七、结论·······················································15 八、参考文献···················································15 九、致谢·······················································20 十、综述·······················································21 十一、参考文献·················································27 2 慢性阻塞性肺病急性加重期患者纤维蛋白原、血浆 D-二聚体检测的临床意义 中文摘要 目的：探讨慢性阻塞性肺病加重期（Acute Exacerbation of Chronic Obstructive Pulmonary Disease，AECOPD）及稳定期患者纤维蛋白原（FIB）、血浆 D-聚体 （D-D）的变化及其临床意义。 方法：分别检测 28 例 COPD 急性加重期患者，30 例 COPD 稳定期以及 10 例健 康体检者（对照组）血浆纤维蛋白原和 D-二聚体含量，分析比较各组间血浆纤 维蛋白原和 D-二聚体含量的差异。 结果：COPD 急性加重期患者与 COPD 稳定期患者比较，FIB、D-D 升高明显， 差异有统计学意义（P0.05）；COPD 急性加重期患者与健康对照组比较，FIB、 D-D 升高，差异有统计学意义（P0.05）；而 COPD 稳定期组与对照组比较，FIB、 D-D 也升高，但差异无统计学意义（P0.05）。 结论：COPD 患者存在血液高凝状态，且随着病情的加重而加重，监测 COPD 患 者血浆中纤维蛋白原和 D-二聚体水平，有助于临床医生及时了解 COPD 患者体 内凝血状况，并为合理使用抗凝剂提供依据，可能有助于改善患者临床预后，减 少病死率。 关键词：慢性阻塞性肺疾病，D-二聚体，纤维蛋白原，抗凝 3 The clinical value of plasma fibrinogen and D-dimer in patients with acute exacerbation of chronic obstructive pulmonary disease Abstract Objective: To explore the changes of plasma fibrinogen（FIB）and D-dimer（D-D） in the patients with acute exacerbation and stable stage of chronic obstructive pulmonary disease (COPD) and their clinical significance. Methods: 28 patients with acute exacerbation of COPD,30 patients with table stage of COPD and 30 cases as control were detected plasma FIB and D-D. Results: Plasma FIB and D-D in the patients with acute exacerbatin ofCOPD were significantly higher than those in the stable stage of COPDand the control group ,the difference showing statistical(P0.05).