山豆根化学成分及生物活性的研究-药物分析学专业毕业论文.docxVIP

山豆根化学成分及生物活性的研究-药物分析学专业毕业论文.docx

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Studies Studies on the chemical constituents of the rhizomes of Sophora J■ Z移以鼻西张2以S蓦S and tlieir DiOaCtIvlneS Author:Qi—Ming Pan Supervisor:Dong Liang Major:Organic Chemistry Research:Natural Organic Chemistry Grade:2013 Abstract In order to find bioactive components from natural products,we studied systematically on the chemical constituents of the alkaloid extract of the rhizomes of Sophora tonkinensis. Through various chromatographic methods and spectral technologies,42 compounds were isolated and identified,including 5 new compounds and 1 new natural product. &tonkinensis(Leguminosae)is mainly distributed in Guangxi,Guizhou,Yunnan, Guangdong and Jiangxi provinces of China.Its roots and rhizomes have historically been used for the treatment of pyrexia,inflammation,acute pharyngolaryneal infections and sore throats. Modem scientific studies demonstrated that the plant contains alkaloids,flavonoids and lignans as its major constituents.As the principal bioactive constituents ofS.tonkinensis are alkaloids,It possesses a wide range of pharmacological activities,such as antitumor and antiviral activities. To ful血er discover bioactive constituents,42 compounds were isolated from the alkaloid extract of S.tonkinensis.The compounds were identified via physicochemical propeaies and spectroscopic data analyses,including 27 alkaloids(1-27),5 flavonoids(28-32),4 lignans (33-36)and 6 others(37-42).Their structures were elucidated as (+)一5a-hydroxyoxysophocarpine(1),(-)-1 2fl-hydroxyoxysophocarpine(2), (+)一5a—hydroxylemannine(3),㈠一sophocarpine(4),㈠一53一hydroxysophocarpine(5), (.)-9a—hydroxysophocarpine(6),(+)一1 2a-hydroxysophocarpine(7), 0—1 2猡-hydroxysophocarpine(8),(+)-oxysophocarpine(9),(+)-matrine(10),(+)-sophoranol (1 1),(+)-9a—hydroxymatrine(12),0-14fl-hydroxymatrine(13),(+)-oxymatrine(14), (+).5a-hydroxyoxymatrine(is),(-)一14fl-hydroxyoxymatrine(16),(+)-sophoramine(17), (-)-N-methylcytisine(18),O—N-ethylcytisine(19),O—N-formylcytisine(20), (-)-N-acety

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