联合应用透明质酸钠和曲安奈德对兔术后肠粘连预防作用的研究-外科学专业论文.docxVIP

对照组比较，应用透明质酸钠组、曲安奈德组以及联合应用透明质酸钠和曲 对照组比较，应用透明质酸钠组、曲安奈德组以及联合应用透明质酸钠和曲 安奈德组，均有减少血内纤维蛋白原的作用(0．01P0．05)，联合用药组更加 明显(PO．01)。(3)术后十四天，粘连程度肉眼分级：和对照组比较，应用透 明质酸钠组、曲安奈德组以及联合应用透明质酸钠和曲安奈德组，均有减轻 粘连松解术后局部肠粘连的作用(O．01PO．05)，联合用药组更加明显 (PO．01)。 结论 联合应用透明质酸钠和曲安奈德不但对兔术后肠粘连有显著的预防作 用，而且对于肠粘连松解术后再次粘连有显著的预防作用，另外联合用药对 血中纤维蛋白原含量有减少作用，并且效果均较单用透明质酸钠和曲安奈德 明显。 关键词 肠粘连；预防和治疗：透明质酸钠；曲安奈德； 2 ■STUDY ■ STUDY ON THE EFFECT OF COMBIND USE OF NATRIUM HYALURONIC ACID AND TRIAMCINOLONE ACETONIDE ON THE PREVENTION OF POSTOPERATIVE INTESTINAL ADHESION OF RABBITS． M．S．Candidate：Li．B0 Department：Pedi atric Surgery Tutor：Prof．Feng Li-lin ABSTRACT Objective To put intra—abdominal surgery into practice for rabbits combined application of natrium hyaluronic acid and triamcinolone acetonide，and study the preventing effect of postoperative period of rabbit intra—abdominal bowel adhesion by combined application of natrium hyaluronic acid and triamcinolone acetonide． Methods 1．Make model，then observe the effect of animals of giving medicine on 。the first day．The first day，64 mature male New Zealand rabbits are utilized as referenee of intestinal adhensive models．Postoperative will follow the same conditions of animal feed cage points．On the first day，which the first batch of 32 surgical animals are randomly divided into 4 groups，group A，group B，group C，and group D，each group of 8．Respectively in the wound nothing，hyaluronic acid sodium，triamcinolone acetonide，and combined application of sodium hyaluronate and triamcinolone acetonide．Seven days later，the first batch of rabbits is executed．Open the abdominal and observe the macroscopic classification of adhesion．Then take the front wall of ascending colon and the adhesion organization in the pathologic observation． 2．Take the blood samples to quantitate the FIB．Take the blood samples on the first day before the surgeries to quantitate the FIB，and take again on the 7 day after surgeries． 3．Observe the effect of pharmacy to adhesion for local bowel function after su