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RAPID COMMUNICATION Circ J 2007; 71: 990 –992
Guidelines for Diagnosis of Takotsubo
(Ampulla) Cardiomyopathy
Sachio Kawai, MD; Akira Kitabatake, MD*; Hitonobu Tomoike, MD**;
Takotsubo Cardiomyopathy Study Group***
Background It is important to differentiate takotsubo cardiomyopathy from other types of transient ventricular
dysfunction. These guidelines, resulting from a workshop sponsored by the Ministry of Health, Labour, and
Welfare, Idiopathic Cardiomyopathy Research Committee, outline the steps necessary for diagnosis of takotsubo
cardiomyopathy.
Methods and Results The survey was conducted by mailing a questionnaire to the researchers of the 203 insti-
tutions that had made presentations on this disease at scientific meetings of the Japanese Circulation Society
from November 1989 to October 2002. The questionnaires were sent and collected on January 10, 2003. Based
on the results of the questionnaire, the first edition of the guidelines for diagnosis of takotsubo cardiomyopathy
was prepared and evaluated at the 2003 group meeting of the Research Committee. Out of 33 researchers in
Japan who had published research papers on this disease, 21 responded to the request and provided their opin-
ions. The guidelines were revised and were approved at the 2004 group meeting.
Conclusions This summary provides standard guidelines for patients with takotsubo cardiomyopathy. (Circ J
2007; 71: 990 –992)
Key Words: Apical ballooning; Myocardial stunning; Ventricular dysfunction
he diagnostic criteria were developed by a consensus
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