氯吡格雷联合阿司匹林治疗短暂性脑缺血发作疗效及对复发影响.docVIP

氯毗格雷联合阿司匹林治疗短暂性脑缺血发作疗效及对复发影响 郑海燕 (四川省广汉市人民医院神经内科 四川 广汉618300) 【摘要】口的：通过临床观察氯毗格雷联合阿司匹林治疗短暂性脑缺血发 作疗效及安全性，同时观察其患者凝血指标影响，从而可为临床短暂性脑缺血发 作患者治疗提供参考。方法：按照随机数字表法将本次76例短暂性脑缺血发作 患者分组为对照组与治疗组，各38例。对照组阿司匹林及阿托伐他汀治疗；治 疗组于对照组治疗基础上加用氯毗格雷治疗。统计与比较两组患者临床疗效、治 疗前后凝血指标变化即凝血酶原时间(PT)和纤维蛋白原(FIB)及活化部分凝血活酶 时间(APTT)、不良反应。随访6个月，统计两组患者复发情况。结果：治疗组临 床治疗总有效者与复发者分别为32例、2例，对照组为24例、12例，然治疗组 治疗总有效率为84.2%明显高于对照组63.2%,复发率5.3%明显低于对照组31.6%, 具有统计学意义，Plt;0.05o两组患者治疗后PT、APTT较治疗前明显增加，而 FIB较治疗前显著下降，但治疗组改善较对照组显著，具有统计学意义，Plt;0.05o 两组患者治疗期间未见明显不良反应。结论：临床应用氯毗格雷联合阿司匹林治 疗短暂性脑缺血发作患者，其可有效改善患者凝血指标，提高临床疗效，减少复 发。同时具有较高安全性，因此可进一步研究、推广。 【关键词】氯毗格雷；阿司匹林；短暂性脑缺血发作；复发 【中图分类号】R742 【文献标识码】A 【文章编号】2095-1752 (2016) 07-0038-02 Clopidogrel plus aspirin therapy Transient ischemic attack efficacy and effects on relapse Zheng Haiyan. The Peoples Hospital of Guanghan City, Sichuan Provinee, Guanghan 618300, China 【Abstract] Objective Through clinical observation of clopidogrel plus aspirin therapy Transient ischemic attack efficacy and safety, while observing their coagulation parameters in patients affected, which may be clinically Transient ischemic attack patients to provide a ref ere nee. Methods According to a ran dom number table in this 76 cases of transient cerebral ischemic attack patients grouped as the control group and the treatment group, 38 cases each? Aspirin group and atorvastatin treatment; treatment group, based on the use of clopidogrel in the control group. Statistics were compared with clinical efficacy in patients before and after treatment coagulation changes that prothrombin time (PT) and fibrinogen (FIB) and activated partial thromboplastin time (APTT), adverse reactions. 6-month follow-up, patients were relapse statistics.Results The total effective treatment group, those with clinical relapse were 32 cases, 2 cases in the control group 24 cases, 12 cases, however, the total effective rate of treatment group was significantly higher than 63.2% 84.2% recurrenee rate of 5.3% was significantly 31.6 percent lower tha