组蛋白甲基化与脂肪生成.docxVIP

组蛋白甲基化与脂肪形成 摘要 最近的研究表明，在脂肪形成过程中，很多基因的表达受到表观遗传的调控。组蛋白甲基化是一种重要的表观遗传学修饰，人们对其已经进行了深入的研究。组蛋白甲基化可以通过调控脂肪细胞分化过程中转录因子及脂肪组织特异性基因的表达，从而调控脂肪组织的形成。该文综述了脂肪形成过程中组蛋白甲基化及去甲基化表观调控的最新进展，探讨了脂肪组织组蛋白甲基化的研究趋势和未来发展方向。 关键词 组蛋白甲基化；脂肪形成；基因表达；组蛋白甲基转移酶；组蛋白去甲基化酶 随着经济的不断发展，肥胖已经成为全球性的公共健康问题，Ⅱ型糖尿病的发生占所有糖尿病的90%-95%，肥胖是Ⅱ型糖尿病的首要危险因素；肥胖还能增加某些类型癌症的发病风险，包括乳腺癌、肾癌、卵巢癌、胰腺癌、前列腺癌、肝癌、大肠癌、黑色素瘤等 ADDIN EN.CITE EndNoteCiteAuthorSanchez/AuthorYear2014/YearRecNum173/RecNumDisplayText(1)/DisplayTextrecordrec-number173/rec-numberforeign-keyskey app=EN db-id=5z5d5sx5http96esasxpwpa5rx2zwztvrtva173/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorSanchez, C./authorauthorIbanez, C./authorauthorKlaassen, J./author/authors/contributorsauth-addressSanchez, C#xD;Pontificia Univ Catolica Chile, Dept Hematol Oncol, Diagonal Paraguay 319, Santiago, Chile#xD;Pontificia Univ Catolica Chile, Dept Hematol Oncol, Diagonal Paraguay 319, Santiago, Chile#xD;Pontificia Univ Catolica Chile, Dept Hematol Oncol, Santiago, Chile#xD;Pontificia Univ Catolica Chile, Fac Med, Ctr Canc, Dept Nutr Diabet amp; Metab, Santiago, Chile/auth-addresstitlestitleThe link between obesity and cancer/titlesecondary-titleRevista Medica De Chile/secondary-titlealt-titleRev Med Chile/alt-title/titlesperiodicalfull-titleRev Med Chil/full-titleabbr-1Revista medica de Chile/abbr-1/periodicalpages211-221/pagesvolume142/volumenumber2/numberkeywordskeywordbariatric surgery/keywordkeywordneoplasms/keywordkeywordsecond primary/keywordkeywordobesity/keywordkeywordbody-mass index/keywordkeywordbreast-cancer/keywordkeywordprostate-cancer/keywordkeywordbariatric surgery/keywordkeywordendometrial cancer/keywordkeywordphysical-activity/keywordkeywordovarian-cancer/keywordkeywordrisk/keywordkeywordchemotherapy/keywordkeywordmanagement/keyword/keywordsdatesyear2014/yearpub-datesdateFeb/date/pub-dates/datesisbn0034-9887/isbnaccession-numWOS:000334816600010/accession-numurlsrelated-urlsurllt;Go to ISIgt;://WOS:000334816600010/url/related-urls/u