鸦胆子油乳注射液联合放射治疗中晚期食管癌的.docVIP

鸦胆子油乳注射液联合放射治疗中晚期食管癌的 疗效观察 何丽佳，罗惠群，向莉 四川泸州 泸州医学院附属医院肿瘤科 646000 摘要 目的 观察鸦胆子油乳注射液联合放射治疗对中晚期食管癌的近期疗效和生存质量的影响。方法 70例中晚期食管癌患者随机分为2组，35例单纯放射治疗，35例在放射治疗同时给予鸦胆子油乳注射液30ml加入生理盐水250ml液中静脉滴注,每天1次,连续18～27天，观察两组在近期疗效，放疗副反应和生存质量上的差异。结果 放射治疗组和放射治疗+鸦胆子组的总有效率分别为72%和75%，P ＞0.05，无统计学意义；生存质量相关评价，两组卡氏评分＞90分以上分别为25.7%和40%,体重减轻Ⅰ度分别为60%和74.3%，血红蛋白＞100g/L分别为85.7%和97.1%和，吞咽困难Ⅰ度22.9%和28.6%， P＜0.05。常见的放疗副反应为恶心呕吐、白细胞下降、放射性食管炎，两组发生率分别为34.2%和20.0%、22.8%和25.7%、51.4%和40.0%， P＜0.05。结论 鸦胆子油乳注射液 关键词：鸦胆子油；放射治疗；食管癌；疗效观察 Efficacy of Brucea Javanica Oil Emulsion Combined radiotherapy on Treating Advanced Esophageal Carcionma HE Li-jia, Luo Hui-qun, Xiang li. Department of Oncology, the Affiliated Hospital of Sichuan Luzhou Medical College, Luzhou 646000,China Abstract：Objective To observe Brucea javanica oil emulsion combined with radiotherapy for advanced esophageal cancer short-term efficacy and quality of life. Methods 70 cases of esophageal cancer patients were randomly divided into two groups, 35 cases given conventional radiotherapy, 35 cases for Brucea javanica oil emulsion plus radiotherapy，30 ml per day, for 21 consecutive days. Two groups were observed in the efficacy, toxicity, and quality of life differences. Results Radiotherapy group and Brucea javanica group CR + PR rates were 72% and 75%, P ＞0.05, KPS score 90 points or more were 25.7% and 40%,Ⅰ degree of weight loss, 74.3% and 60%, hemoglobin 100g / L were 97.1% and 85.7%, P＜0.05. Malignant vomiting, leukopenia, radiation esophagitis, Two groups were 34.2% and 20.0%, 22.8% and 25.7%, 51.4% and 40.0%, P＜0.05. Conclusion Brucea javanica oil emulsion combined with radiotherapy for advanced esophageal cancer does not improve in the short-term effect，But it can significantly improve patient quality of life and reducing radiation toxicity. Key word：brucea javanica oil；radiotherapy；esophageal carcinoma; efficacy 我国是食管癌的高发国家，每年新发病例占世界发病人数的50%。由于食管癌病人在诊断时大多属于中晚期，放射治疗是其主要的治疗手段，而单纯放疗疗效差，毒副反应较重，严重影响了患者的生存质量。我们将中晚期食管癌在常规放射治疗基础上加用