三种激素剂型治疗嗜酸性粒细胞型鼻息肉的疗效及安全性研究.PDFVIP

CHIN ARCH OTOLARYNGOL HEAD NECK SURG / April 2019, Vol.26, No.4 199 DOI: 10.16066/j.1672-7002.2019.04.008 三种激素剂型治疗嗜酸性粒细胞型鼻息肉的疗效及安全性研究 1，2 1 1 1 1，2 ，3 王阳 ，黄嫣然，娄鸿飞，王成硕，张罗 1 北京市耳鼻咽喉科研究所，鼻病研究北京市重点实验室，北京　100005；首都医科大学附属北京同仁医院 2 耳鼻咽喉头颈外 科，3 变态（过敏）反应科，北京　100730 [摘　要]　目的　比较口服、经鼻雾化吸入和鼻喷激素 dr.luozhang@139.com) 对嗜酸性粒细胞型慢性鼻-鼻窦炎伴鼻息肉（eosinophilic [ABSTRACT]　OBJECTIVE　To compare the efficacy and chronic rhinosinusitis with nasal polyps ，ECRSwNP ）2周 safety of the three forms of steroids(oral and intranasal forms, 治疗的疗效和安全性。 　60例ECRSwNP患者，随机 transnasal nebulization) in the management of eosinophilic 方法 分为：A 组口服泼尼松，B组经鼻雾化吸入布地奈德混悬 chronic rhinosinusitis with nasal polyps(ECRSwNP) in a two- 液，C组布地奈德喷鼻治疗。治疗前、后评估鼻部症状、 week treatment. METHODS　Sixty patients with ECRSwNP 内镜息肉评分。评估治疗前、后鼻息肉组织的嗜酸性粒 were randomized into three groups: group A for oral 细胞阳离子蛋白和白细胞介素5表达含量。以不良事件 prednisone, group B for transnasal nebulization of Pulmicort 来评估其安全性。 　三组患者鼻部症状治疗后均显 inhalation suspension and group C for budesonide nasal spray. 结果 P 0.001 ）。A 、B组鼻部症状的改善明显优于C 着改善（ Nasal symptoms and nasal polyp scores were assessed both 组。只有A 、B组患者的鼻息肉体积在治疗后有明显改善 before and after treatment. Similarly, nasal polyp samples P 0.001 ）。B 、C组均未发生不良事件，A 组中有2例患 （ were evaluated for eosinophil cationic protein and interleukin 者由于不良事件而退出研究。 　经鼻雾化吸入治疗 结论 5. Adverse events were evaluated as safety outcomes. ECRSwNP安全有效，可作为ECRSwNP常规治疗方法。 RESULTS　Compared with the baseline in the three [关键词]　嗜酸细胞；鼻窦炎；鼻息肉；糖皮质激素类；投 groups, significant improvements could be seen in nasal