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电喷雾萃取电离质谱法检测呼出气体中乙腈的分析.pdf 54页

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东华理工大学硕士学位论文 II 万方数据 ABSTRACT 东华理工大学研究生毕业论文英文摘要首页用纸 THESIS: The Detection of Acetonitrile in Human Breath by Extractive Electrospray Ionization Mass Spectrometry SPECIALIZATION: Analytical Chemistry POSTGRADUATE: Yan Zhang MENTOR: Prof. Huanwen Chen ABSTRACT Breath analysis by virtue of its potential medical research value, and as a non-invasive sample, simple sampling and continuous available is of interest for modern clinical diagnosis and metabonomics. The concentration levels of acetonitrile, an important biomarker in human exhaled gas, are correlated with human health. This paper introduces physical and chemical properties of acetonitrile; reviews detection methods of actonitrile in analytical science and important application values of mass spectrometry in breath analysis. And researchs the application of extractive electrospraying ionization mass spectrometry in detection of acetonitrile in human exhaled breath. Then, established a novel platform for direct and indirect detection of acetonitrile, and applying these methods to study metabonomics and clinical diagnosis. The main research content of this thesis involves as following: 1) The important value of breath detection and acetonitrile in human breath detection are descriped. Reviews the mechanism, advantages and disadvantages of the methods that used for detect acetonitrile in human exhaled breath. Indroduces the mechanism and application value of extractive electrospray ioniza

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