第一讲-举例1-化学生物学.ppt

Chemical Biology Chemical Biology What is Chemical Biology? Chemical methods used in Biology Why Chemical Biology? Chemistry, Physics – Physical Science Biology – Non-physical Science ? Promoting Multi-disciplinary Research ? Science and Technology Development ? Knowledge Innovation ? International Academic Exchange ? Etc. ? Medical Biology ? Molecular Biology ? Cell Biology ? Molecular Genetics ? Pathology ? Virology ? Bacteriology ? Neurology ? Hematology ? Epidemiology ? Pharmacology ? Physiology ? Microbiology ? Structural Biology ? Protein Biology ? Immunology ? Etc. ? Biology ? Biochemistry ? Biophysics ? Biomedicine ? Bioagriculture ? Bioanalytical ? Biodiversity ? Biomaterials ? Biopolymer ? Biocatalysis ? Etc. Funds for physical sciences (mostly chemistry, physics, and astronomy) have remained flat while life sciences have soared. The Nobel Prize in Chemistry has been gived to scientists in research of biomacromolecules (DNA, RNA, Proteins) for 3 years. We can see how important life science is in the domain of Chemistry. There are some Nobel Prize winners: The Nobel Prize in Chemistry 2002 Developing New Methods for Visualization of biomacromolecules John B.Fenn "for the development of methods for identification and structureanalyses of biological macromolecules" Koichi Tanaka "for their development of softdesorption ionization methods for mass spectrometric analyses of biological macromolecules" Kurt Wuthrich "for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution" Electrospray ionization mass spectrometry (ESI-MS) of a protein ? John B. Fenn: ESI-MS ? Koichi Tanaka: MALDI-MS (Matrix-assisted laser desorption/ionization MS) ? Kurt Wuthrich: A wide variety of NMR methods for biomacromolecules The Nobel Prize in Chemistry 2003 The structure and function of Ion Channels (bacterial KcsA K+ channel) The K+ channel discriminates again