组蛋白赖氨酸甲基转移酶SET8对蛋白的甲基化修饰及-中国肿瘤临床.pdfVIP

中国肿瘤临床2015年第42卷第15期 ChinJClinOncol2015.Vol.42.No.15 765 国家基金研究进展综述 · · 组蛋白赖氨酸甲基转移酶SET8对蛋白的甲基化 修饰及与肿瘤相关性的研究进展* ① ①② ① 刘奔 张熙凝 陈可欣 摘要 组蛋白赖氨酸甲基转移酶SET8属于SET基因家族成员，是目前发现的唯一可以特异性催化H4赖氨酸20单甲基化 （H4K20me1）的赖氨酸甲基转移酶（KMTs）；此外，SET8还可甲基化p53、TWIST、Wnt及ERα等非组蛋白，并通过调节转录过程影 响相应基因的表达，进而参与调控细胞周期、染色质固缩和DNA的复制。有研究提示，SET8的单核苷酸多态性与多种肿瘤的发 生发展有潜在的相关性。本文就SET8对组蛋白和非组蛋白的修饰、microRNA对SET8的调节及SET8与肿瘤相关性的研究进展 进行了综述，旨在为揭示肿瘤的发病机制和筛选治疗靶点提供帮助。 关键词 SET8 组蛋白甲基转移酶 表观遗传修饰 肿瘤发生 doi:10.3969/j.issn.1000-8179 Research progress on histone lysine methyltransferase SET8 in methylation modification and association with tumor 1 1, 2 1 Ben LIU , Xining ZHANG , Kexin CHEN Correspondence to: Kexin CHEN; E-mail: chenkexin@ 1Department of Epidemiology and Biostatistics, Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Tianjin Key Laboratory of Cancer Prevention and Therapy; Key Laboratory 2 of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China; Graduate School of Tianjin Medical University, Tianjin 300070, China. This study was supported by the National Natural Science Foundation of China (No. and the Science Technology Development Project Foundation of Tianjin Colleges and Universities (No.. Abstract SET8 is a member of SET gene family. SET8 is the only hist