改良坐骨神经慢性压迫性损伤模型的建立.pdfVIP

改良坐骨神经慢性压迫性损伤模型的建立 王金保, 聂发传v (, 400038) : : : SD 24 3, CCI CC I sham ( ), ( 0 d) 2468101214 d () : CCI CC I, CC I, CCI: CC I, , , : 神经病理性疼痛; 坐骨神经; 模型, 动物; 大鼠, Sprague-Daw le : R33-33 : A : 1009-0878( 2007) 03-0001-03 Establishment of theM odels of the Improved Chronic Constriction Injury of the SciaticNerve WANG Jin-bao, NIE Fa-chuan( Pain C lin ic Cen ter, Southw est H ospital, Th irdM ilitar M ed icalUn ivers it , Chongqing 400038, China) Abstract: Objective:The ami of th is stud is to estab lish a feasib le and stable anmi alm odel of chronic constriction nerve injur . M ethods: Tw ent -four pathogen-free adu lt m ale Sprague-Daw le rats w ere random l d ivided in to th ree groups ( traditional CCI group, mi proved CC I group and sham group). The threshold of nerve injured h ind paw to therm al stmi u lus ( pain threshold) and behavioral changes w ere recorded before operation and 2, 4, 6, 8, 10, 12, 14 da s after operation. Results: The rats in both the traditionalCCI group and mi proved CC I group in- d icated t pical h peralgesia phenom ena, and the pain threshold in both the groups decreased sign ificantl. Com pared to the traditional CC I group, the h peralgesia phenom ena in rats of the mi proved CC I group ex isted for a stab le and longer tmi e. Conclusion: The mi proved CC I m odel seem ed to be stable and reliable, reducing infection factors. It also seemed that the mi proved CC Im odel shou ld be usefu l for studies, particu larl in the aspect of mi m unem echanism. K ey ords:Neuropath ic pain; Sciatic nerve; M odel, an mi al; Rats, Sprague-Daw le ( chron ic constr iction injur ), 8 of the sciatic nerve, CCI)( neu- ropath ic pain, NPP) CCI 112 RTY-1, , , 113 [ 1]