骨髓瘤硼替佐米耐药相关突变.pptxVIP

MM硼替佐米相关突变;NRAS、KRAS PSMB5 NF-κB通路持续活化相关 HSP:HSP90 HSP27;方法：MassARRAY? DNA质谱阵列基因分析 NRAS-MUT: 1、硼替佐米单药耐药相关 2、PFS时间短 3、不影响硼替佐米联合大剂量DEX方案化疗的患者的预后 ;Interestingly, KRAS but not NRASmutation was significantly associated with TP53 mutation (15% of those with KRAS mutation versus 3% of those without, P = 0.014). when we analyzed the impact of KRAS and NRAS mutations on survival separately, only KRAS and not NRAS mutations were significantly associated with shorter overall survival and progression free survival.;体外实验：we here developed high levels