普通楼 部分题目 (2).doc

医学免疫学电子资料/dispbbs.asp?boardID=241&ID=3042695 Questions: Please describe the concepts of TD-Ag and TI-Ag respectively and compare the differences between TD-Ag and TI-Ag. Thymus -dependent antigens are those that do not directly stimulate the production of antibody without the help of T cells. B cell epitope ＋ T cell epitope Humoral immunity and cellular immunity Antibody :five types Immune memory Proteins are thymus -dependent antigens. Thymus -independent antigens are antigens which can directly stimulate the B cells to produce antibody without the requirement for T cell help In general. only B cell epitope Humoral immunity Antibody: IgM No Immune memory polysaccharides are TI- antigens. Please describe the general properties of cytokine. General properties of CKs Small proteins (MW: approx. 15-30 KD) Extremely potent, acting at pM or fM The production is transient and tightly regulated Autocrine, paracrine or endocrine Non-specific and non-MHC restricted What are the rules of antibody production in vivo? (What are the general features of antibody responses in vivo?) B cell and HMI ppt P65.表格作参考，表格下的文字为主。 eq \o\ac(○,B) Primary response Secondary response Lag after immunization Usually 5-10 days Usually 1-3 days Peak response Smaller Larger Antibody isotype Usually IgM>IgG Relative increase in IgG and, under certain situations, in IgA or IgE(heavy chain class switching) Antibody affinity Lower average affinity, more variable Higher average affinity(affinity maturation) Primary immune response - longer latent phase; - smaller peak response (lower Ab titer); - remaining in the serum at detectable  levels for much shorter periods; - lower average affinity; - usually IgM; Secondary immune response (The immune response followed by secondary antigenic challenge) - shorter latent phase; - bigger peak response (higher Ab titer); - remaining in the serum at detectable levels for much longer periods; - higher average affinity;