原发性闭角型青光眼眼血流动力学改变.docVIP

???? 原发性闭角型青光眼眼血流动力学改变 ???? ????　摘要：为探讨原发性闭角型青光眼的发病机理，采用彩色超声多普勒成像(CDI)对115例原发性闭角型青光眼患者的眼血流动力学改变进行了检测，结果发现，急、慢性闭角型青光眼患者各组眼动脉和视网膜中央动脉的血流参数指标均表现为收缩期峰值速度(PSV)、舒张末期速度(EDV)和平均血流速度(AV)的降低，阻力指数(RI)和搏动指数(PI)的升高。在各血流参数中以急性闭角型青光眼急性发作期组的变异最显著，慢性闭角型青光眼组次之，急性闭角型青光眼慢性期组再次之。说明原发性闭角型青光眼患者的眼动脉和视网膜中央动脉的血流速度下降明显，血流阻力增加，眼局部血液循环障碍。　　关键词：原发性闭角型青光眼；彩色超声多普勒成像；眼血流动力学　　中分类号：R775.2　　文献标识码：B　　文章编号：1000-5633(2000)03-0004-03 Changes of Ocular Hemodynamics in PrimaryAngle-Closed Glaucoma PENG Qinghua，LI Chuanke(The First Affiliated Hospital,Hunan University of TCM， Changsha 410007) 　　Abstract:To ivestigate ocular hemodynamics with color Doppler imagine(CDI),115 Patients with primary closedangle glaucoma(PCG) were studied.Results: In acute angle-closure glaucoma and chronic angle-closure glaucoma,peak systolic velocity(PSV)、end diastolic velocity(EDV) and average velocity(AV) of the ophthalmic artery(OA) and the central retinal artery(CRA)reduced,resistive index(RI) and pulsatility index(PI) of OA and CRA ascended.In blood flow parameter,the variance of acute angle-closure glaucoma acute lhase was large,the variance of chronic angle-closure was inferior,the variance of acute angle-closure glaucoma chromic phase was small. Blood flow relocities of OA and CRA in PCG were lower than those in the nomal sudjucts,the resistance of the blood flow increase,ocular blood circulation obstacle.　　Key words:primary closedangle glaucoma;color Doppler;ocular hemodynamics 　　原发性闭角型青光眼是一种以眼压升高，压迫眼内组织，使其缺血缺氧，进而引起视功能障碍甚至丧失的临床常见病，相当于中医“绿风内障”范畴。为对其辨证治疗用药提供参考依据，我们对115例原发性闭角型青光眼患者的眼部进行超声多普勒检测，从眼血流动力学角度探讨原发性闭角型青光眼的发病机理，报告如下。1　资料与方法1.1　临床资料　　115例原发性闭角型青光眼患者为本院就诊患者，根据其临床表现，分为慢性闭角型、急性闭角型急性发作期和急性闭角型慢性期3组。另设正常对照组24例，各组情况如下。　　慢性闭角型青光眼组(以下简称“慢闭组”)：共47例59只眼，既往无眼部手术及外伤史。其中男19例，女28例；年龄41～68岁，平均(54.31±9.68)岁。急性闭角型青光眼急性发作期组(以下简称“急闭Ⅰ组”)：共32例36只眼，既往无眼部手术及外伤史。其中男14例，女18例；年龄42～67岁，平均(53.74±10.05)岁。急性闭角型青光眼慢性期组(以下简称“急闭Ⅱ组”)：共36例47只眼，既往无眼部手术及外伤史。其中男15例，女21例；年龄40～68岁，平均(54.06±9.74)岁。正常对照组：共24例48只眼。为经检查排除眼部疾患及心、脑、肾、肝病、外周血管疾病和外伤的健康人