食管鳞癌中雄激素受体与缺氧诱导因子-1α的表达及其关系.doc

食管鳞癌中雄激素受体与缺氧诱导因子 -1α的表达及其关系 张英国 ?个人简介：张英国（1974-）男，汉族，硕士，主治医师。 ?个人简介：张英国（1974-）男，汉族，硕士，主治医师。。 通讯作者：高秉仁 教授，博士生导师,e-mail :bingrengao@ 兰州大学第二医院心胸外科 兰州 730000 【摘要】 目的：探讨雄激素受体（AR）与缺氧诱导因子-1α(HIF-1α)在食管鳞癌患者中的表达及其相互关系。方法：采用免疫组织化学SP法对67例食管鳞癌及30例正常食管组织中AR与HIF-1α进行检测，结合临床病理特征进行分析。结果：AR与HIF-1α在食管鳞癌中的表达水平明显高于正常食管粘膜组织（P 均<0.01）。AR与HIF-1α的表达与食管鳞癌的分化程度、浸润深度、淋巴结反应增生、淋巴结转移、临床分期有关，且AR与性别有关（P 均 <0.05）。AR与HIF-1a之间明显相关性（r = 0.277,P <0.05）。结论：AR、HIF-1α与食管癌生物学行为关系密切，二者的过度表达可能共同参与了食管癌的发生、发展过程。 【关键词】：雄激素受体；缺氧诱导因子-1α；食管鳞状细胞癌 The Expression of AR and HIF-1a and their relationships in esophageal squamous cell carcinoma ZHANG Ying-guo, GAO Bing-ren, CHEN Wen-shen, et al Department of Cardio-Thoracic Surgery,The Second Affiliated Hospital of Lan Zhou University,LanZhou 730000,China 【Abstract】 Objective: To study the expression of Androgen receptor (AR) and Hypoxia inducible factor-1alpha (HIF-1a) and their relationships in esophageal squamous cell carcinoma(ESCC). Methods: SP immunohistochemical staining was used to examine the expression of HIF-1α and AR in 67 cases of ESCC and 30 cases of normal esophageal tissue.The relationships of AR and HIF-1a to the clinical pathologic features of ESCC were analyzed. Results：The expression of AR and HIF-1a in ESCC were significantly higher than those in normal esophageal mucosal epithelium(P all﹤0.01)，The expression of HIF-1α and AR were significantly correlated with the depth of tumour invasion,differentiation, reactive proliferation of lymphnode, lymphnode metastasis and clinical stage of ESCC, in addition AR related to gender (P all <0.05).The expression of AR and HIF-1α in ESCC were positively correlated(r =0.277,P <0.05). Conclusion：The expression of AR and HIF-1α have close relationships with the biologic behavior of esophageal squamous cell carcinoma, The AR and HIF-la protein might take part in the occurrence, development and lymph node metastasis of human esophageal carcinoma. 【Key words】： Androgen receptor(AR)；Hypoxia-inducible