纳米炭示踪胃癌前哨淋巴结的实验研究.pdfVIP

DOC格式论文，方便您的复制修改删 纳米炭示踪胃癌前哨淋巴结的实验研究 （作者:___________单位: ___________邮编: ___________） 作者：陈卫东，汤文浩，柏志斌 【摘要】 目的：通过纳米炭示踪兔胃癌前哨淋巴结的对照研究， 为纳米炭应用于胃癌的临床研究打下基础。方法：兔胃癌病灶周围浆 膜下分别注射99Tcm SC 和纳米炭混悬液（卡纳琳），记录两种示踪 法检测到前哨淋巴结（SLN）的例数、SLN 数目及分布情况，计算两 种示踪法检测SLN 的敏感性、特异性、假阴性率和预测区域淋巴结转 移的准确性以及SLN 和非前哨淋巴结（NSLN）的转移率。结果：纳米 炭与99Tcm SC SLN 的检出率及数目，显示SLN 分布情况、SLN 的转 移率差异均无统计学意义（P＞0.05）。两种示踪法检测SLN 的敏感性、 特异性、假阴性率、准确性差异均无统计学意义（P＞0.05）。结论： 纳米炭示踪胃癌前哨淋巴结效果与放射性核素99Tcm SC 是一致的， 但纳米碳示踪法具有显影快而持久、无放射性、使用方便等优点，可 替代放射性核素用于胃癌的临床研究。 【关键词】胃癌； 前哨淋巴结； 纳米炭 ［Abstract ］Objective: To evaluate the clinical DOC格式论文，方便您的复制修改删减 application o nano carbon in visualization o sentinel lymph node (SLN) in gastric cancer surgery.Methods: Rabbit gastric cancer model was established by transplantation of VX2 cells into the gastric serosa.Nano carbon and 99Tcm SC were injected respectively into the gastric wall in rabbit model o gastric cancer.The cases,the numbers and the distribution o SLN were documented.Then the sensibility,specificity,false negative rate and the accurate rate o local lymph node metastasis were calculated,the metastasis ratio of SLN,NSLN were evaluated.Results:As far as the isolating rate,the numbers,the distribution and the metastasis rate of SLN was concerned,no significant di erence was shown between the two groups （P＞0.05）.Moreover,the sensibility,specificity,false negative rate and the accurate rate o local lymph node metastasis were not di erence between two groups （P ＞ 0.05 ）.Conclusions:Nano carbon has a similar e ect with 99Tcm SC in SLN visualization.Furthermore,it can be used in gastric cancer surgery to replace radionuclide,considering its quick detection,non radioactivity and convenience. ［Key words ］ gastric cancer; sentinel lymph node; nano carbon DOC格式论文，方便您的复制修