Salicylate-induced peripheral auditory changes and tonotopic reorganization of auditory cortex英文精品课件.pdf
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Neuroscience 180 (2011) 157–164
SALICYLATE-INDUCED PERIPHERAL AUDITORY CHANGES AND
TONOTOPIC REORGANIZATION OF AUDITORY CORTEX
a a a
D. STOLZBERG, * G.-D. CHEN, B. L. ALLMAN AND the general population. A recent assessment indicates
R. J. SALVIa,b approximately 25.3% of the United States adult population
aCenter for Hearing and Deafness, State University of New York at has experienced some tinnitus, while 7.9% reported expe-
Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA riencing tinnitus frequently (Shargorodsky et al., 2010).
bDepartment of Communicative Disorders and Sciences, State Uni- Tinnitus affects an estimated 1–3% of the population to a
versity of New York at Buffalo, 137 Cary Hall, 3435 Main Street, degree which negatively impacts many aspects of their
Buffalo, NY 14214, USA
lives (Dobie, 2003). Despite increased attention in recent
years, a cohesive physiological framework underlying tin-
Abstract—The neuronal mechanism underlying the phantom nitus generation remains elusive.
auditory perception of tinnitus remains elusive at present. The current state of tinnitus research suggests that
For over 25 years, temporary tinnitus following acute salicy-
peripheral deafferentation—that is, altered peripheral in-
late intoxication in rats has been used as a model to under-
stand how a phantom sound can be generated. Behavioral put—is the mo
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