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Sammy Bedoui CD4 T-cell help amplifies innate
William R. Heath +
Scott N. Mueller signals for primary CD8 T-cell
immunity
Authors’ addresses Summary: CD8+ T cells provide an important component of protection
Sammy Bedoui1, William R. Heath1,2, Scott N. Mueller1,2 against intracellular infections and cancer. Immune responses by these
1Department of Microbiology and Immunology, The T cells involve a primary phase of effector expansion and differentia-
University of Melbourne, Peter Doherty Institute for tion, followed by a contraction phase leading to memory formation
Infection and Immunity, Parkville, Vic., Australia. and, if antigen is re-encountered, a secondary expansion phase with
2The Australian Research Council Centre of Excellence in more rapid differentiation. Both primary and secondary phases of
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Advanced Molecular Imaging, The University of CD8 T-cell immunity have been shown to depend on CD4 T-cell
Melbourne, Parkville, Vic., Australia. help, although during certain infections the primary phase is variable
in this requirement. One explanation for such variability relates to the
Correspondence to: strength of associa
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