基础免疫学基础免疫学1Activation of lymphocyte cytolytic machinery_ where are we.pdf

REVIEW ARTICLE published: 19 November 2013 doi: 10.3389/fimmu.2013.00390 Activation of lymphocyte cytolytic machinery: where are we? Ricciarda Galandrini 1 *, Cristina Capuano1 and Angela Santoni 2 1 Department of Experimental Medicine, Istituto Pasteur-Fondazione Cenci-Bolognetti, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza University, Rome, Italy 2 Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci-Bolognetti, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza University, Rome, Italy Edited by: Target cell recognition by cytotoxic lymphocytes implies the simultaneous engagement Konrad Krzewski, National Institutes and clustering of adhesion and activating receptors followed by the activation of an array of of Health, USA signal transduction pathways. The cytotoxic immune synapse represents the highly spe- Reviewed by: Jordan Orange, Baylor College of cialized dynamic interface formed between the cytolytic effector and its target that allows Medicine, USA temporal and spatial integration of signals responsible for a defined sequence of processes Eric O. Long, National Institute of culminating with the polarized secretion of lytic granules. Over the last decades, much Allergy and Infectious Diseases, USA attention has been given to the molecular signals coupling receptor ligation to the activa- *Correspondence: tion of cytolytic machinery. Moreover, in the last 10 years the discovery of genetic defects Ricciarda Galandrini, Dep