小儿麻醉和丙泊酚.ppt

小儿麻醉与两泊酚 予传 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 背景 丙泊酚用于3岁以下的赑幼儿的药理学知识有限 许多国家不允许在这个年龄范围应用丙泊酚 ■在此年龄段成功应用丙泊酚的报告不多 ■有在儿童的长期镇静中应用丙泊酚引起并发症 和死亡的报告 ■新西兰的报告:甚至在早产儿中应用丙泊酚 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 丙泊酚短效、速效、苏醒快 极少引起呛咳、恶心 可单独用于无痈操作,对某些 创伤性操作往往需加用麻醉 名小溶中的网用 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L pH7.0-8.5 三空模型 I相快速分布相2~3min ∏相快速清除相34~56min 相慢速清除相184~480min Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 药物在肝脏通过葡萄糖醛 酸化代谢 新生儿葡萄糖醛酸化速度 较慢可通过与硫酸盐结合 而得到代偿 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 麻醉诱号 95%病人可使用2.4mg/kg 随着年龄增长1.5mg/kg可以诱 导入睡 懊用鵔大剃量可較早发生呼吸抑制 维持剂量50~200g/kg/min (3-12mg/kg/h Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 单次静脉注射后: 收缩压下降20.94% 舒张压下降28.2% 平均压下降24.23% 心率下降10% 用药后4min下降幅度最大,均可自行恢复 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 单次静脉注射后: 87.5%出现一过性SpO下降, 下降幅度15% 面罩吸氧即可纠治 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 本药可控性大,苏醒快,很少 呕吐 尤其造用予手泶蜜外麻醉 Evaluation only. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L 丙泊酚能用于小婴儿吗? Evaluation only. ch Asposeslides fo